Utf1: Goldilocks for ESC Bivalency.

Journal: 
Cell Stem Cell
Publication Year: 
2012
Authors: 
Agnieszka I Laskowski , Paul S Knoepfler
Public Summary: 
Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.
Scientific Abstract: 
Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.

© 2013 California Institute for Regenerative Medicine