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Information about disease focus, human stem cell use or new cell line generation will typically not be available on the website until a few months after the award is announced. Disease categories are provided for awards that might impact a given disease or related area, whether those awards are for translational research on new therapy candidates or for basic research to address a biological question that is relevant to that disease.
Institution Researcher name Grant Type Grant Title ICOC Approved Funds
Children's Hospital of Los Angeles Tracy Grikscheit New Faculty II Mechanism of Tissue Engineered Small Intestine Formation $3,415,000
San Diego State University Ricardo Zayas New Faculty II The molecular basis underlying adult neurogenesis during regeneration and tissue renewal $1,725,830
University of California, San Francisco Samuel Pleasure Comprehensive Grant Human stem cell derived oligodendrocytes for treatment of stroke and MS $2,566,701
University of California, Irvine Marian Waterman Basic Biology II TCF-3: A Wnt Pathway Effector and Nanog Regulator in Pluripotent Stem Cell Self-Renewal $1,277,101
University of California, San Diego Dong-Er Zhang Basic Biology II RUNX1 in maintenance, expansion, and differentiation of therapeutic pluripotent stem cells $1,371,540
University of California, San Francisco Holger Willenbring New Faculty II Molecular dissection of adult liver regeneration to guide the generation of hepatocytes from pluripotent stem cells $3,207,510
Sanford-Burnham Medical Research Institute Stuart Lipton Comprehensive Grant MEF2C-Directed Neurogenesis From Human Embryonic Stem Cells $3,035,996
University of California, San Francisco Jeffrey Bluestone Transplantation Immunology Stem cell tolerance through the use of engineered antigen-specific regulatory T cells $1,152,768
University of California, Los Angeles Zack Jerome Comprehensive Grant Human Embryonic Stem Cell Therapeutic Strategies to Target HIV Disease $2,516,831
University of California, San Diego Kun-Liang Guan Basic Biology II The function of YAP in human embryonic stem cells $1,340,565
The J. David Gladstone Institutes Yadong Huang New Faculty II Defining the Isoform-Specific Effects of Apolipoprotein E on the Development of iPS Cells into Functional Neurons in Vitro and in Vivo $2,847,600
Stanford University Irving Weissman Comprehensive Grant Prospective isolation of hESC-derived hematopoietic and cardiomyocyte stem cells $2,636,900
University of California, San Francisco Tippi MacKenzie Transplantation Immunology Maternal and Fetal Immune Responses to In Utero Hematopoietic Stem Cell Transplantation $1,324,229
Stanford University Christopher Zarins Comprehensive Grant Engineering a Cardiovascular Tissue Graft from Human Embryonic Stem Cells $2,618,704
University of California, Los Angeles Benhur Lee Basic Biology II The EphrinB2/EphB4 axis in regulating hESC pluripotency and differentiation $1,371,936
University of California, San Diego Benjamin Yu New Faculty II Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins $3,231,649
University of California, Irvine Peter Donovan Comprehensive Grant Improved hES Cell Growth and Differentiation $2,509,438
University of California, Irvine Hans Keirstead Comprehensive Grant hESC-Derived Motor Neurons For the Treatment of Cervical Spinal Cord Injury $2,396,932
Stanford University Aaron Hsueh Basic Biology II Maturation of Human Oocytes for SCNT and Embryonic Stem Cell Derivation $1,432,197
Stanford University Ching-Pin Chang New Faculty II VEGF signaling in adventitial stem cells in vascular physiology and disease $3,330,931
University of California, San Francisco Andrew Leavitt Comprehensive Grant Understanding hESC-based Hematopoiesis for Therapeutic Benefit $2,566,702
University of California, San Francisco Arnold Kriegstein Comprehensive Grant Derivation of Inhibitory Nerve Cells from Human Embryonic Stem Cells $2,507,223
The Salk Institute for Biological Studies Ronald Evans Basic Biology II Molecular Characterization and Functional Exploration of Nuclear Receptors in hiPSCs $1,712,880
University of California, San Diego Catriona Jamieson New Faculty II Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells $3,065,572
University of California, Irvine Douglas Wallace Comprehensive Grant The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning $2,530,000
iPierian, Inc. John Dimos Basic Biology II Cellular Reprogramming: Dissecting the Molecular Mechanism and Enhancing Efficiency $1,458,000
University of California, Irvine Edwin Monuki New Faculty II Mechanisms in Choroid Plexus Epithelial Development $3,169,328
Escape Therapeutics, Inc Basil Hantash Transplantation Immunology Development of an immune tolerant hESC source for allogeneic cell therapy applications $1,453,040
University of California, Los Angeles Gay Crooks Comprehensive Grant Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC) $2,551,088
The J. David Gladstone Institutes Deepak Srivastava Comprehensive Grant microRNA Regulation of Cardiomyocyte Differentiation from Human Embryonic Stem Cells $3,164,000
University of California, Davis Eric Kurzrock Basic Biology II Differentiation of Human Embryonic Stem Cells into Urothelium $1,328,400
University of Southern California Gage DeKoeyer Crump New Faculty II Skeletogenic Neural Crest Cells in Embryonic Development and Adult Regeneration of the Jaw $2,396,871
Palo Alto Institute for Research and Education, Inc. Husein Hadeiba Transplantation Immunology Application of Tolerogenic Dendritic Cells for Hematopoietic Stem Cell Transplantation $885,475
Scripps Research Institute Nicholas Gascoigne Transplantation Immunology Role of Innate Immunity in hematopoeitic stem cell-mediated allograft tolerance $1,746,684
University of California, Los Angeles Guoping Fan Comprehensive Grant Epigenetic gene regulation during the differentiation of human embryonic stem cells: Impact on neural repair $2,516,613
University of California, San Francisco Jeremy Reiter New Faculty II High throughput modeling of human neurodegenerative diseases in embryonic stem cells $2,259,092
University of California, Los Angeles Gay Crooks Transplantation Immunology Engineering Thymic Regeneration to Induce Tolerance $1,357,398
Stanford University Stefan Heller Comprehensive Grant Generation of inner ear sensory cells from human ES cells toward a cure for deafness $2,469,373
University of California, San Francisco Susan Fisher Comprehensive Grant Constructing a fate map of the human embryo $2,532,388
Palo Alto Institute for Research and Education, Inc. Tony Wyss-Coray Basic Biology II Systemic Protein Factors as Modulators of the Aging Neurogenic Niche $1,522,800
University of California, Merced Kara McCloskey New Faculty II Building Cardiac Tissue from Stem Cells and Natural Matrices $1,706,255
University of California, San Francisco Randall Lee Comprehensive Grant Embryonic Stem Cell-Derived Therapies Targeting Cardiac Ischemic Disease $2,524,617
University of California, Los Angeles Douglas Black Basic Biology II Programs of alternative splicing regulation by polypyrimidine tract binding protein $1,350,994
Stanford University Roel Nusse Comprehensive Grant Guiding the developmental program of human embryonic stem cells by isolated Wnt factors $2,354,820
University of California, San Diego Lawrence Goldstein Comprehensive Grant Using Human Embryonic Stem Cells to Understand and to Develop New Therapies for Alzheimer's Disease $2,512,664
University of California, Los Angeles Yong Kim Basic Biology II Novel Mechanism in Self-Renewal/Differentiation of Human Embryonic Stem Cells $1,259,371
University of California, Los Angeles Antoni Ribas New Faculty II Stem Cells for Immune System Regeneration to Fight Cancer $3,247,000
University of California, Berkeley Lin He New Faculty II The roles of non-coding RNAs in the self-renewal and differentiation of pluripotent stem cells $1,499,994
University of California, San Diego Martin Marsala Comprehensive Grant Spinal ischemic paraplegia: modulation by human embryonic stem cell implant $2,445,716
Stanford University Steven Artandi Basic Biology II Self-renewal and senescence in iPS cells derived from patients with a stem cell disease $1,430,908
The J. David Gladstone Institutes Benoit Bruneau New Faculty II Induction of cardiogenesis in pluripotent cells via chromatin remodeling factors $2,847,600
University of California, Los Angeles Brigitte Gomperts New Faculty II Stem Cells in Lung Cancer $2,556,572
University of California, San Diego Mana Parast New Faculty II Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal $3,253,580
University of California, San Diego Yang Xu Comprehensive Grant Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells $2,570,000
Sanford-Burnham Medical Research Institute Mark Mercola Comprehensive Grant Chemical Genetic Approach to Production of hESC-derived Cardiomyocytes $3,036,002
Sanford-Burnham Medical Research Institute Huei-sheng Chen Basic Biology II Endothelial cells and ion channel maturation of human stem cell-derived cardiomyocytes $1,823,362
Ludwig Institute for Cancer Research Bing Ren New Faculty II Mechanisms of chromatin dynamics at enhancers during ES cell differentiation $1,726,564
University of California, San Francisco Ophir Klein New Faculty II Laying the groundwork for building a tooth: analysis of dental epithelial stem cells $3,250,251
Stanford University Christopher Contag Transplantation Immunology Engineering Embryonic Stem Cell Allografts for Operational Tolerance $1,447,956
Stanford University Julie Baker Comprehensive Grant Functional Genomic Analysis of Chemically Defined Human Embryonic Stem Cell $2,628,635
University of California, San Francisco John Rubenstein Basic Biology II MGE Enhancers to Select for Interneuron Precursors Produced from Human ES Cells $1,387,800
Stanford University Alfred Lane Disease Team Research I iPS Cell-Based Treatment of Dominant Dystrophic Epidermolysis Bullosa $11,709,574
Beckman Research Institute of City of Hope Karen Aboody Disease Team Research I Stem Cell-mediated Therapy for High-grade Glioma: Toward Phase I-II Clinical Trials $18,015,429
Stanford University Gary Steinberg Disease Team Research I Embryonic-Derived Neural Stem Cells for Treatment of Motor Sequelae following Sub-cortical Stroke $20,000,000
University of California, Los Angeles Dennis Slamon Disease Team Research I THERAPEUTIC OPPORTUNITIES TO TARGET TUMOR INITIATING CELLS IN SOLID TUMORS $19,979,660
University of California, Los Angeles Donald Kohn Disease Team Research I Stem Cell Gene Therapy for Sickle Cell Disease $9,212,365
Stanford University Irving Weissman Disease Team Research I Development of Therapeutic Antibodies Targeting Human Acute Myeloid Leukemia Stem Cells $19,999,996
ViaCyte, Inc. Allan Robins Disease Team Research I Cell Therapy for Diabetes $22,999,937
Cedars-Sinai Medical Center Eduardo Marbán Disease Team Research I Autologous cardiac-derived cells for advanced ischemic cardiomyopathy $5,560,232
Calimmune, Inc. Geoff Symonds Disease Team Research I GENE-MODIFIED HEMATOPOIETIC STEM/PROGENITOR CELL BASED THERAPY FOR HIV DISEASE $8,278,722
Beckman Research Institute of City of Hope John Zaia Disease Team Research I ZIinc Finger Nuclease-Based Stem Cell Therapy for AIDS $14,583,187
University of California, Los Angeles Irvin Chen Early Translational from Disease Team Conversion HPSC based therapy for HIV disease using RNAi to CCR5. $1,505,000
University of California, Los Angeles Irvin Chen Disease Team Research I HPSC based therapy for HIV disease using RNAi to CCR5. $9,905,604
University of California, San Francisco Mitchel Berger Disease Team Research I Stem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM) $19,162,435
University of Southern California Mark Humayun Disease Team Research I Stem cell based treatment strategy for Age-related Macular Degeneration (AMD) $18,904,916
University of California, San Diego Lawrence Goldstein Disease Team Research I Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $10,857,762
University of California, San Diego Dennis Carson Disease Team Research I Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) $19,999,826
University of California, San Francisco Linda Giudice Shared Labs Shared Research and Teaching Laboratory: a Non-Federal Human Embryonic Stem Cell Resource for the Bay Area Community $5,546,877
University of California, Santa Barbara Dennis Clegg Shared Labs Laboratory for Stem Cell Biology and Engineering $3,161,329
University of California, Davis Alice Tarantal Shared Labs Translational Human Embryonic Stem Cell Shared Research Facility $3,709,631
University of California, Berkeley David Schaffer Shared Labs Human Embryonic Stem Cell Shared Research Laboratory $2,929,237
University of California, Riverside Prudence Talbot Shared Labs A Stem Cell Core Facility for Studying Human Embryonic Stem Cell Differentiation $3,658,353
Scripps Research Institute Jeanne Loring Shared Labs Center for hESC Research $3,828,751
Sanford-Burnham Medical Research Institute Evan Snyder Shared Labs Collaborative Laboratory for Human Embryonic Stem Cell Research $4,762,725
Stanford University Renee Reijo Pera Shared Labs Center for Human Embryonic Stem Cell Research and Education $5,819,047
University of California, San Diego Karl Willert Shared Labs Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells $3,711,102
Buck Institute for Age Research Xianmin Zeng Shared Labs CIRM Shared Research Laboratory for Stem Cells and Aging $5,883,026
The J. David Gladstone Institutes Deepak Srivastava Shared Labs CIRM Shared Human Embryonic Stem Cell Core Laboratory $2,621,345
University of California, Santa Cruz Lindsay Hinck Shared Labs Shared Stem Cell Facility $3,588,740
University of California, Los Angeles Owen Witte Shared Labs CIRM Shared Research Laboratories $3,740,497
The Salk Institute for Biological Studies Inder Verma Shared Labs Shared viral vector facility for genetic manipulation of human ES cell $4,316,515
University of California, Irvine Peter Donovan Shared Labs Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course $5,572,979
Children's Hospital of Los Angeles David Warburton Shared Labs hESC Facility $3,756,666
University of Southern California Andrew McMahon Shared Labs Center for Stem Cell and Regenerative Medicine: Shared Research Laboratory and Course in Current Protocols in Human Embryonic Stem Cell Research $5,355,969
Stanford University Anne Brunet Basic Biology IV Energy metabolism and aging pathways in human stem cell reprogramming and differentiation $1,414,044
Stanford University Michael Cleary Basic Biology IV Prostaglandin pathway regulation of self-renwal in hematopoietic and leukemia stem cells $1,244,455
University of California, Davis Deborah Lieu Basic Biology IV Induction of Pluripotent Stem Cell-Derived Pacemaking Cells $1,334,880
Beckman Research Institute of City of Hope Yanhong Shi Basic Biology IV Modeling Alexander disease using patient-specific induced pluripotent stem cells $1,367,172
University of California, San Francisco Miguel Ramalho-Santos Basic Biology IV Genetic dissection of human cellular reprogramming to pluripotency $1,184,883
University of California, San Diego Maike Sander Basic Biology IV Deciphering transcriptional control of pancreatic beta-cell maturation in vitro $1,391,400
Total:
$445,938,214.00

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