The histone demethylase UTX enables RB-dependent cell fate control.

Journal: 
Genes Dev
Publication Year: 
2010
Authors: 
Jordon K Wang , Miao-Chih Tsai , Gino Poulin , Adam S Adler , Shuzhen Chen , Helen Liu , Yang Shi , Howard Y Chang
Public Summary: 
Scientific Abstract: 
Trimethylation of histone H3 on Lys 27 (H3K27me3) is key for cell fate regulation. The H3K27me3 demethylase UTX functions in development and tumor suppression with undefined mechanisms. Here, genome-wide chromatin occupancy analysis of UTX and associated histone modifications reveals distinct classes of UTX target genes, including genes encoding Retinoblastoma (RB)-binding proteins. UTX removes H3K27me3 and maintains expression of several RB-binding proteins, enabling cell cycle arrest. Genetic interactions in mammalian cells and Caenorhabditis elegans show that UTX regulates cell fates via RB-dependent pathways. Thus, UTX defines an evolutionarily conserved mechanism to enable coordinate transcription of a RB network in cell fate control.

© 2013 California Institute for Regenerative Medicine