Directed Differentiation of Specialized Endothelial Cells

Directed Differentiation of Specialized Endothelial Cells

Funding Type: 
Basic Biology V
Grant Number: 
RB5-07414
Award Value: 
$476,052
Disease Focus: 
Vascular Disease
Stem Cell Use: 
Embryonic Stem Cell
Status: 
Active
Public Abstract: 
Vascular endothelial cells (EC) or endothelial progenitor cells (EPC) derived from stem cells could potentially lead to a variety of clinically relevant therapeutic applications, including various strategies for treating heart and vascular diseases. However, because EC exhibit a variety of functionally distinct subphenotypes, it is important to be able to generate the appropriate endothelial type. This study will explore the limits and importance of EC fate and generate methodologies for directing EC subphenotypes.
Statement of Benefit to California: 
Vascular endothelial cells (EC) or endothelial progenitor cells (EPC) derived from stem cells could potentially lead to a variety of clinically relevant therapeutic applications, including various strategies for treating heart and vascular diseases. However, because EC exhibit a variety of functionally distinct subphenotypes, it is important to be able to generate the appropriate endothelial type. This study will explore the limits and importance of EC fate and generate methodologies for directing EC subphenotypes for treating these patients.

© 2013 California Institute for Regenerative Medicine