A novel druggable mechanism to safeguard stem cell genome

A novel druggable mechanism to safeguard stem cell genome

Funding Type: 
Basic Biology V
Grant Number: 
RB5-07285
Award Value: 
$1,423,800
Stem Cell Use: 
Adult Stem Cell
Embryonic Stem Cell
Status: 
Active
Public Abstract: 
Safeguarding the genome is essential for cells’ proper functions, and more importantly for safe and efficacious applications involving pluripotent stem cells and adult stem cells. However, how pluripotent or somatic stem cells maintain genome integrity during self-renewal, differentiation, and reprogramming is still largely unknown. We recently identified a small molecule drug that exhibits unprecedented abilities in maintaining and enhancing genome stability of pluripotent stem cells under stress conditions. The proposed studies aim to uncover the small molecule’s mechanisms and utilities in human pluripotent and adult stem cells. These studies will lead to improved understanding to safeguard stem cell genome, provide a safer and more robust approach in stem cell ex vivo expansion, and allow new therapeutic development toward treating diseases and aging associated with genome instability as well as promoting in vivo stem cell protection.
Statement of Benefit to California: 
The proposed studies will lead to improved understanding to safeguard stem cell genome, provide a safer and more robust approach in stem cell ex vivo expansion, and allow new therapeutic development toward treating diseases and aging associated with genome instability as well as promoting in vivo stem cell protection.

© 2013 California Institute for Regenerative Medicine