University of California, Los Angeles

Award Value
Basic Biology I: Luisa Iruela-Arispe Overcoming the chromatin barrier during reprogramming $1,371,477
Basic Biology II: Yong Kim In Vitro Generation of Normal and Neoplastic Intestinal Stem Cells $1,259,371
Basic Biology II: Douglas Black Aging and Renewal of iPS Cells During Reprogramming, Propagation and Differentiation $1,344,562
Basic Biology II: Douglas Black A bioinformatic approach to study context-specific signaling by the stem cell receptor Kit $1,344,562
Basic Biology II: Douglas Black Purification and Analysis of Genes That Regulate Self-Renewal and Differentiation $1,344,562
Disease Team Research I: Dennis Slamon Using Nell-1 to harness the osteogenic potential of adult stem cells $19,979,660
Disease Team Research I: Donald Kohn WALQ team for saving limbs and keeping Californians on their feet $8,834,129
Basic Biology I: Michael Teitell The molecular mechanism of epigenetic reprogramming by defined factors $1,323,029
Basic Biology I: Michael Teitell A systems biology approach to elucidating the mechanisms underlying self-renewal of human ES cells $1,323,029
Basic Biology I: Michael Teitell Control of Human Embryonic Stem Cell Self-Renewal, Pluripotency and Differentiation $1,323,029
Basic Biology I: Michael Teitell Mechanisms of Lineage Commitment in Human Neural Crest Stem Cells $1,323,029
Basic Biology I: Robb Maclellan Efficient T cell development from human pluripotent stem cells by LRF/Pokemon inactivation $917,667
Basic Biology I: Luisa Iruela-Arispe MicroRNAs as regulators of pluripotence and reprogramming $1,371,477
Basic Biology I: Luisa Iruela-Arispe Beta-Cell Differentiation from Adult Human Pancreatic Stem/Progenitor Cells $1,371,477
Basic Biology I: Luisa Iruela-Arispe Genetic Instability of Pluripotent Cells and the Impact on Differentiation Capacity $1,371,477
Basic Biology I: Luisa Iruela-Arispe Mechanobiological control of human pluripotent stem cell neurogenesis $1,371,477
Basic Biology II: Benhur Lee Molecular determinants of stem cell fate during hPSC differentiation into skeletal muscle $1,371,936
Basic Biology II: Benhur Lee Circuitry of Cell Cycle Control in Human Pluripotent Stem Cells $1,371,936
Basic Biology II: Benhur Lee Novel Strategies to Generate Large-Scale Cultures of Human Hematopoietic Progenitors $1,371,936
SEED Grant: Hanna Mikkola Human Embryonic Stem Cell Therapy for Retinal Degeneration $550,241
SEED Grant: Hanna Mikkola hESC mitochondrial transfer to empower withered cardiomyocytes $550,241
SEED Grant: Hanna Mikkola Development of Blood and Liver Stem Cells from Embryonic Stem Cells $550,241
SEED Grant: Hanna Mikkola Optimized hESC Cultures Using Microfluidics $550,241
SEED Grant: Noriyuki Kasahara Gene Targeting in Human ES Cells $399,239
SEED Grant: Michael Teitell Derivation of Human Embryonic Stem Cell-Like Cells from the Testis $570,800
SEED Grant: Michael Teitell An Integrated Microfluidic Platform for Screening hESC Culture Conditions $570,800
Basic Biology II: Benhur Lee The mechanism of the multipotency of human cardiac progenitors $1,371,936
Basic Biology II: Benhur Lee Translational Control of Dopaminergic Neuron Differentiation and Survival in hPSCs $1,371,936
SEED Grant: William Lowry Stem Cell Transdifferentiation in the Testis $528,096
SEED Grant: Siavash Kurdistani Stem Cell Lipid Organization $549,698
SEED Grant: William Lowry Analysis of the Mode of Division of Human Embryonic Stem Cells $528,096
New Faculty I: Dana Jones Characterization of mechanisms regulating de-differentiation and the re-acquisition of stem cell identity $382,773
Early Translational II: Sophie Deng Regeneration of Functional Human Corneal Epithelial Progenitor Cells $0
Early Translational II: Sophie Deng Regeneration of Functional Human Corneal Epithelial Progenitor Cells $1,524,947
New Faculty I: Kathrin Plath In vitro reprogramming of mouse and human somatic cells to an embryonic state $2,229,427
Early Translational II: Bruno Peault Harnessing native fat-residing stem cells for bone regeneration $5,359,076
Basic Biology III: Ali Nsair Characterization and Engineering of the Cardiac Stem Cell Niche $1,163,618
Basic Biology III: Shuo Lin Etsrp/ER71 mediated stem cell differentiation into vascular lineage $1,382,400
Basic Biology III: William Lowry Molecular determinants of accurate differentiation from human pluripotent stem cells $677,115
Tools and Technologies II: Martin Martin Pluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders $1,783,250
Basic Biology IV: Kathrin Plath Understanding the status of the X chromosomes in human ESCs and preimplantation embryos $1,382,400
Basic Biology IV: Owen Witte Trop2 dependent and independent mechanisms of self-renewal in human cancer stem cells $1,254,960
Early Translational II: Noriyuki Kasahara Stem cell-based carriers for RCR vector delivery to glioblastoma $3,370,607
Disease Team Research I: Donald Kohn Stem Cell Gene Therapy for Sickle Cell Disease $8,834,129
Basic Biology III: Kathrin Plath Discovery of mechanisms that control epigenetic states in human reprogramming and pluripotent cells $1,364,598
Basic Biology III: Yi Sun Studying neurotransmission of normal and diseased human ES cell-derived neurons in vivo $1,382,400
Basic Biology III: Gay Crooks Forming the Hematopoietic Niche from Human Pluripotent Stem Cells $1,252,857
New Faculty II: Brigitte Gomperts Stem Cells in Lung Cancer $2,381,572
New Cell Lines: Zack Jerome Generation of clinical grade human iPS cells $1,341,000
SEED Grant: Hanna Mikkola Improving microenvironments to promote hematopoietic stem cell development from human embryonic stem cells $550,241
SEED Grant: Siavash Kurdistani Cellular epigenetic diversity as a blueprint for defining the identity and functional potential of human embryonic stem cells $549,698
SEED Grant: Noriyuki Kasahara Down-Regulation of Alloreactive Immune Responses to hES Cell-Derived Graft Tissues $399,239
SEED Grant: Zoran Galic Genetic Enhancement of the Immune Response to Melanoma via hESC-derived T cells $616,800
Early Translational I: Gabriel Travis Development of a Stem Cell-based Transplantation Strategy for Treating Age-related Macular Degeneration $5,487,136
SEED Grant: Michael Teitell Role of Mitochondria in Self-Renewal Versus Differentiation of Human Embryonic Stem Cells $570,800
SEED Grant: William Lowry Modeling Human Embryonic Development with Human Embryonic Stem Cells $528,096
Comprehensive Grant: Gay Crooks Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC) $1,653,416
Comprehensive Grant: Zack Jerome Human Embryonic Stem Cell Therapeutic Strategies to Target HIV Disease $2,401,903
SEED Grant: Irvin Chen Genetic modification of the human genome to resist HIV-1 infection and/or disease progression $616,800
New Cell Lines: Amander Clark Generation of Pluripotent Cell Lines from Human Embryos $1,168,501
Basic Biology I: Luisa Iruela-Arispe Molecular Characterization and Functional Exploration of Hemogenic Endothelium $1,371,477
Basic Biology I: Bennett Novitch Molecular Characterization of hESC and hIPSC-Derived Spinal Motor Neurons $1,229,922
Basic Biology I: Michael Teitell Mitochondrial Metabolism in hESC and hiPSC Differentiation, Reprogramming, and Cancer $1,323,029
Basic Biology II: Douglas Black Programs of alternative splicing regulation by polypyrimidine tract binding protein $1,344,562
Basic Biology II: Yong Kim Novel Mechanism in Self-Renewal/Differentiation of Human Embryonic Stem Cells $1,259,371
Basic Biology II: Benhur Lee The EphrinB2/EphB4 axis in regulating hESC pluripotency and differentiation $1,371,936
Basic Biology I: Robb Maclellan Human Cardiovascular Progenitors, their Niches and Control of Self-renewal and Cell Fate $917,667
Transplantation Immunology: Gay Crooks Engineering Thymic Regeneration to Induce Tolerance $1,235,445
Comprehensive Grant: Guoping Fan Epigenetic gene regulation during the differentiation of human embryonic stem cells: Impact on neural repair $2,412,995
Shared Labs: Owen Witte CIRM Shared Research Laboratories $1,751,297
Shared Labs: Scott Waugh CIRM Shared Research Laboratories $2,000,000
Disease Team Research I: Dennis Slamon THERAPEUTIC OPPORTUNITIES TO TARGET TUMOR INITIATING CELLS IN SOLID TUMORS $19,979,660
Disease Team Research I: Irvin Chen HPSC based therapy for HIV disease using RNAi to CCR5. $9,905,604
New Faculty II: Antoni Ribas Stem Cells for Immune System Regeneration to Fight Cancer $3,072,000
New Faculty I: Siavash Kurdistani Epigenetics in cancer stem cell initiation and clinical outcome prediction $3,063,450
New Faculty I: Hanna Mikkola Mechanisms of Hematopoietic stem cell Specification and Self-Renewal $2,286,900
Tools and Technologies II: Stanley Carmichael Development of a Hydrogel Matrix for Stem Cell Growth and Neural Repair after Stroke $1,825,613
Tools and Technologies II: Richard Gatti Use of hiPSCs to develop lead compounds for the treatment of genetic diseases $1,833,054
Research Training II: Kenneth Dorshkind CIRM Research Training Program II $7,898,444
New Faculty Physician Scientist: Ali Nsair Human Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells for Cardiac Cell Therapy. $175,000
New Faculty Physician Scientist: Ali Nsair Human Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells for Cardiac Cell Therapy. $3,004,315
New Faculty Physician Scientist: Reza Ardehali Preclinical evaluation of human embryonic stem cell-derived cardiovascular progenitors $2,930,388
Early Translational IV: Zack Jerome Stem Cell Programming With Chimeric Antigen Receptors to Eradicate HIV Infection $4,925,166
Disease Team Therapy Development III: Donald Kohn Clinical Trial of Stem Cell Gene Therapy for Sickle Cell Disease $13,935,441
Tissue Collection for Disease Modeling: Brigitte Gomperts Using human induced pluripotent stem cells to improve our understanding of Idiopathic Pulmonary Fibrosis $811,231
Disease Team Therapy Development - Research: Antoni Ribas Genetic Re-programming of Stem Cells to Fight Cancer $19,875,776
Basic Biology V: Denis Evseenko Promoting survival and countering hypertrophy of pluripotent stem cell (PSC)-derived chondrocytes $1,146,468
Genomics Centers of Excellence Awards (R): Stanley Carmichael CIRM Genomics Center of Excellence $42,748
Genomics Centers of Excellence Awards (R): Stanley Carmichael Center for Population and Functional Genomics in Stem Cell Biology and Regenerative Medicine $42,748
Genomics Centers of Excellence Awards (R): Stanley Carmichael Collaborative Center for Stem Cell Genomics $42,748
Genomics Centers of Excellence Awards (R): Stanley Carmichael Center for Advanced Stem Cell Genomics $42,748
Early Translational from Disease Team Conversion: Stanley Nelson Combination therapy to Enhance Antisense Mediated Exon Skipping for Duchenne Muscular Dystrophy $1,829,930
Research Leadership 14: John Chute Niche-Focused Research: Discovery & Development of Hematopoietic Regenerative Factors $5,174,715
Major Facilities: Gene Block UCLA CIRM Institute $19,854,900
Disease Team Therapy Planning I: Stanley Nelson Combination therapy to Enhance Antisense Mediated Exon Skipping for Duchenne Muscular Dystrophy $68,947
Disease Team Therapy Planning I: Antoni Ribas Genetic Re-programming of Stem Cells to Fight Cancer $97,785
Early Translational IV: Robert Reiter Clinical Development of an N-cadherin Antibody to Target Cancer Stem Cells $4,075,668
Training Grant I-1: Owen Witte CIRM Type I Comprehensive Training Program $3,660,398
Early Translational IV: Donald Kohn Beta-Globin Gene Correction of Sickle Cell Disease in Hematopoietic Stem Cells $1,652,076
Early Translational IV: Gerald Lipshutz Gene therapy-corrected autologous hepatocyte-like cells from induced pluripotent stem cells for the treatment of pediatric single enzyme disorders $1,801,629
Total:
$262,264,397.00

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