University of California, San Diego

Award Value
Basic Biology IV: David Traver DECIPHERING THE INSTRUCTIONS FOR VERTEBRATE HSC SPECIFICATION AND AMPLIFICATION. $1,363,698
Basic Biology IV: Maike Sander Deciphering transcriptional control of pancreatic beta-cell maturation in vitro $1,258,560
Basic Biology IV: Miles Wilkinson Role of the NMD RNA Decay Pathway in Maintaining the Stem-Like State $1,360,450
Early Translational II: Alysson Muotri Developing a drug-screening system for Autism Spectrum Disorders using human neurons $1,410,697
Early Translational II: Catriona Jamieson Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy $3,103,041
Basic Biology IV: Ananda Goldrath Mechanisms to protect hESC-derived cells from allogenic immune rejection $1,161,000
Basic Biology IV: Eugene Yeo Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration $1,260,360
Basic Biology IV: George Sen Regulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases. $1,080,000
Basic Biology III: Binhai Zheng Generation and characterization of corticospinal neurons from human embryonic stem cells $1,355,063
Basic Biology III: Eugene Yeo Neural and general splicing factors control self-renewal, neural survival and differentiation $1,287,619
Basic Biology III: David Cheresh Molecular basis of human ES cell neurovascular differentiation and co-patterning $1,359,996
Basic Biology III: Deborah Spector Viral-host interactions affecting neural differentiation of human progenitors $1,372,660
Basic Biology III: Kun Zhang Functional characterization of mutational load in nuclear reprogramming and differentiation $1,295,318
Basic Biology III: Anirvan Ghosh Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells $843,597
Basic Biology III: Farah Sheikh Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC $1,341,955
Basic Biology III: Charles King Biological relevance of microRNAs in hESC differentiation to endocrine pancreas $1,313,649
Transplantation Immunology: Yang Xu Induction of immune tolerance to human embryonic stem cell-derived allografts $1,192,680
Transplantation Immunology: Martin Marsala Induction of immune tolerance after spinal grafting of human ES-derived neural precursors $1,387,800
Early Translational I: Yang Xu Developing induced pluripotent stem cells into human therapeutics and disease models $5,165,028
Comprehensive Grant: Martin Marsala Spinal ischemic paraplegia: modulation by human embryonic stem cell implant $2,356,090
Comprehensive Grant: Lawrence Goldstein Using Human Embryonic Stem Cells to Understand and to Develop New Therapies for Alzheimer's Disease $1,859,414
Comprehensive Grant: Yang Xu Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells $2,467,200
SEED Grant: Sylvia Evans Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells $585,600
SEED Grant: Binhai Zheng Genetic manipulation of human embryonic stem cells and its application in studying CNS development and repair $600,441
SEED Grant: Cornelis Murre Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells $473,952
SEED Grant: Anirvan Ghosh Generation of forebrain neurons from human embryonic stem cells $587,591
SEED Grant: Shu Chien Combinatorial Platform for Optimizing Microenvironments to Control hESC Fate $577,148
New Cell Lines: Steve Dowdy Protein transduction of transcription factors: a non-genetic approach to generate new pluripotent cell lines from human skin. $1,073,585
Basic Biology II: Kun-Liang Guan The function of YAP in human embryonic stem cells $1,245,693
Basic Biology II: Dong-Er Zhang RUNX1 in maintenance, expansion, and differentiation of therapeutic pluripotent stem cells $1,371,540
Basic Biology I: Karl Willert WNT signaling and the control of cell fate decisions in human pluripotent stem cells. $1,329,298
Basic Biology I: Eugene Yeo RNA Binding Protein-mediated Post-transcriptional Networks Regulating HPSC Pluripotency $1,308,901
SEED Grant: Catriona Jamieson Derivation and Characterization of Cancer Stem Cells from Human ES Cells $616,305
Disease Team Research I: Lawrence Goldstein Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $5,694,308
Shared Labs: Karl Willert Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells $1,737,694
Shared Labs: Karl Willert Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells $1,728,080
Disease Team Research I: Dennis Carson Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) $19,999,826
Research Training II: Sylvia Evans Interdisciplinary Stem Cell Training Program $7,890,588
New Faculty Physician Scientist: Mana Parast Human pluripotent stem cell-based therapeutics for preeclampsia $2,974,750
New Faculty II: Benjamin Yu Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins $28,388
New Faculty II: Benjamin Yu Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins $3,017,978
New Faculty II: Catriona Jamieson Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells $3,065,572
New Faculty I: David Traver Genetic dissection of mesodermal commitment to the hematopoietic fates. $2,150,620
Tools and Technologies II: Shu Chien Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation $1,706,628
Tools and Technologies II: Lawrence Goldstein Developing a method for rapid identification of high-quality disease specific hIPSC lines $1,693,667
Tools and Technologies II: Karl Willert Homologous recombination in human pluripotent stem cells using adeno-associated virus. $1,659,043
New Faculty II: Mana Parast Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal $3,078,580
New Faculty II: Shyni Varghese A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment $2,300,569
Basic Biology V: Dianne McKay Role of intracytoplasmic pattern recognition receptors in HSC engraftment $615,639
Basic Biology V: Miles Wilkinson New Regulators of Spermatogonial Stem Cells: RHOX Homeobox Transcription Factors $560,160
Early Translational III: Eugene Yeo Molecules to Correct Aberrant RNA Signature in Human Diseased Neurons $1,532,323
Disease Team Therapy Development III: Thomas Kipps Therapeutic Eradication of Cancer Stem Cells $4,179,598
Basic Biology V: David Cheresh CD61-driven stemness program in epithelial cancer $1,161,000
Early Translational III: Lawrence Goldstein Identifying Drugs for Alzheimer's Disease with Human Neurons Made From Human IPS cells $1,774,420
Early Translational III: Mark Tuszynski Functional Neural Relay Formation by Human Neural Stem Cell Grafting in Spinal Cord Injury $4,600,447
Disease Team Planning: Lawrence Goldstein Human Stem Cell Approaches to Alzheimers Disease Therapies $55,000
Basic Biology V: Lawrence Goldstein Elucidating pathways from hereditary Alzheimer mutations to pathological tau phenotypes $1,050,300
Basic Biology V: Christian Metallo Metabolic regulation of cardiac differentiation and maturation $1,124,834
Basic Biology V: Wei Wang Systems-level discovery of the regulatory mechanisms directing differentiation of hESC $1,161,000
Basic Biology V: Maike Sander Defining links between chromatin state and developmental competence $1,050,300
Disease Team Planning: Dennis Carson CIRM Planning Grant in Leukemia $52,174
Basic Biology V: Cornelis Murre Epigenetic mechanisms that enforce pluripotency in embryonic stem cells $1,161,000
Research Leadership 12: Eric Ahrens Molecular Imaging for Stem Cell Science and Clinical Application $5,924,428
Early Translational III: Eric Adler Identification of Novel Therapeutics for Danon Disease Using an iPS Model of the Disease $1,701,575
Early Translational III: Yang Xu Human ES cell based therapy of heart failure without allogenic immune rejection $1,857,600
Tools and Technologies I: Ying Liu Generation of disease models for neurodegenerative disorders in hESCs by gene targeting $709,829
Training Grant I-1: Lawrence Goldstein Interdisciplinary Stem Cell Training Program at UCSD $3,459,396
Tools and Technologies I: Steve Dowdy TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells $720,000
Tissue Collection for Disease Modeling: Joseph Gleeson CIRM Tissue Collection for Neurodevelopmental Disabilities $830,428
Tissue Collection for Disease Modeling: Douglas Galasko Collection of skin biopsies to prepare fibroblasts from patients with Alzheimer's disease and cognitively healthy elderly controls $643,693
Early Translational IV: Alysson Muotri A drug-screening platform for autism spectrum disorders using human astrocytes $1,656,456
Early Translational from Disease Team Conversion: Lawrence Goldstein Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $4,139,754
Tissue Collection for Disease Modeling: Kang Zhang Generation of fibroblast cell lines in patients with common blinding eye diseases $1,034,425
Total:
$147,847,999.00
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