University of California, Irvine

Award Value
Disease Team Planning: Henry Klassen A translational research project for defining a stem cell formulation for treating ischemic stroke based on comparison of adult neural stem cells and neural stem cells derived from embryonic stem cells. $23,537
SEED Grant: Kyoko Yokomori Role of PK2 on the differentiation of human neural stem cells and ischemia-induced neurogenesis $607,200
SEED Grant: Kyoko Yokomori MicroRNAs in Human Embryonic Stem Cell Self-Renewal and Differentiation $607,200
New Faculty I: Andrew Putnam High throughput modeling of human neurodegenerative diseases in embryonic stem cells $395,764
New Faculty I: Andrew Putnam Designing a microenvironment niche for hepatic differentiation of hESCs $395,764
New Faculty I: Andrew Putnam Stem Cells for Immune System Regeneration to Fight Cancer $395,764
New Faculty I: Andrew Putnam Investigation of the molecular pathways that integrate self-renewal and cell structure in embryonic stem cells. $395,764
New Faculty I: Andrew Putnam A novel and generalizable organotypic slice model to evaluate stem cell potential for targeting pediatric brain tumors $395,764
Early Translational II: Henry Klassen Targeting nanotherapeutics to eradicate acute leukemia stem cells $1,803,768
SEED Grant: Kyoko Yokomori Role of RXR in Nurr1-induced Differentiation of Human ES Cells and in Parkinson's Disease $607,200
SEED Grant: Grant MacGregor 3D_SpineTracker - Automated remyelination detection and classification of axons for sub-acutely injured spinal cord section images for temporal tracking of remyelination after stem cell treatment $385,466
Basic Biology II: Marian Waterman Regulation of Human Thymic Epithelial Cell Development from ESC $1,277,101
SEED Grant: Brian Cummings Exploring the Therapeutic Potential of Human Embryonic Stem Cells in Pediatric Neurotrauma $595,345
SEED Grant: Brian Cummings Cell-Cell Interactions Promote Differentiation of Human Embryonic Stem Cells to Insulin-Secreting Cells $595,345
SEED Grant: Brian Cummings Ovol genes and hES differentiation into hair-producing cells $595,345
SEED Grant: Thomas Lane The role of HER2 signaling in differentiation and maintenance of human embryonic stem cells $368,081
SEED Grant: Thomas Lane Developmental Regulation of Human Embryonic Stem Cells by microRNAs $368,081
SEED Grant: Charles Limoli Treating Stress Urinary Incontinence with Human Embryonic Stem Cells $593,242
SEED Grant: Grant MacGregor Stem cell therapy on hypertension: A potential source and role of nNOS in brainstem $385,466
Early Translational II: Henry Klassen Human derived salivary gland stem cell as a novel therapy for xerostomia $1,803,768
Early Translational II: Henry Klassen Derivation of HIV-Resistant Autologous Progenitor Cells for Treatment of HIV-1 Infection $1,803,768
Basic Biology V: Peter Donovan β-catenin-mediated human embryonic stem cell self-renewal and differentiation $540,480
Basic Biology V: Peter Donovan Mechanism of Direct Lineage Conversion into Induced Motor Neurons $540,480
Basic Biology V: Peter Donovan Endogenous Retroelements as reporters of hESC and iPSC functionality and stability. $540,480
Basic Biology V: Peter Donovan Unraveling the Molecular Wiring that Controls Endothelial Cell Plasticity $540,480
Disease Team Planning: Henry Klassen Development of Novel Therapeutic Strategies for Pulmonary Vascular Disease Using Stem Cells Derived From Patients' Diseased Arterial Tissues $23,537
Disease Team Planning: Henry Klassen Transendocardial Autologous Serum Autologous Mesenchymal Stem Cell delivery using Transendocardial Delivery For Heart Failure Trial $23,537
Disease Team Planning: Henry Klassen Melanoma Stem Cell $23,537
Disease Team Planning: Henry Klassen Development of A Cell-based Therapy for Cerebral Palsy $23,537
Basic Biology V: Lisa Flanagan Mitochondrial dynamics and quality control in hPSC self renewal and differentiation $994,108
Disease Team Therapy Development - Research: Henry Klassen Airways for Children $17,144,825
Early Translational II: Henry Klassen Stem cells for treating focal cartilage injury $1,803,768
Early Translational II: Henry Klassen Human iPSC-derived Cardiac Progenitor Cells for Cardiac Cell Therapy $1,803,768
Early Translational II: Henry Klassen Placental stem cell-based therapy for treatment of acute lung injury $1,803,768
Early Translational III: Craig Walsh iPSC-derived cellular therapeutics for Friedreich’s ataxia $4,590,219
Early Translational III: Craig Walsh Developing a drug screening platform for anorexia nervosa with patient-derived neurons $4,590,219
Early Translational III: Craig Walsh Development of pluripotent-derived hNSC candidate cells for the treatment of chronic SCI $4,590,219
Early Translational III: Craig Walsh IPSC-derived Neo-chondrocytes for Cartilage Regeneration in Osteoarthritis $4,590,219
Early Translational III: Craig Walsh Meniscal Repair, Regeneration, and Replacement $4,590,219
SEED Grant: Grant MacGregor Derivation and Epigenomic Analysis of hES Cells $385,466
Basic Biology II: Aileen Anderson Role of the microenvironment in human iPS and NSC fate and tumorigenesis $1,256,194
SEED Grant: Frank LaFerla Development of human ES cell lines as a model system for Alzheimer disease drug discovery $473,963
SEED Grant: Vincent Procaccio Mitochondrial Dysfunction in Embryonic Stem Cells $245,582
New Faculty II: Edwin Monuki Mechanisms in Choroid Plexus Epithelial Development $2,793,395
Comprehensive Grant: Peter Donovan Improved hES Cell Growth and Differentiation $2,381,713
Comprehensive Grant: Douglas Wallace The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning $1,790,133
Comprehensive Grant: Hans Keirstead hESC-Derived Motor Neurons For the Treatment of Cervical Spinal Cord Injury $2,158,445
Early Translational I: Frank LaFerla Neural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease $3,599,997
Shared Labs: Peter Donovan The University of California: irvine Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course $3,072,500
New Faculty I: Andrew Putnam A Novel Engineered Niche to Explore the Vasculogenic Potential of Embryonic Stem Cells $395,764
SEED Grant: Charles Limoli Using human embryonic stem cells to treat radiation-induced stem cell loss: Benefits vs cancer risk $593,242
SEED Grant: Brian Cummings The Immunological Niche: Effect of immunosuppressant drugs on stem cell proliferation, gene expression, and differentiation in a model of spinal cord injury. $595,345
Basic Biology II: Marian Waterman TCF-3: A Wnt Pathway Effector and Nanog Regulator in Pluripotent Stem Cell Self-Renewal $1,277,101
Early Translational II: Brian Cummings Neural restricted, FAC-sorted, human neural stem cells to treat traumatic brain injury $1,517,767
Early Translational II: Leslie Thompson A hESc-based Development Candidate for Huntington's Disease $4,045,253
Early Translational II: Henry Klassen Human retinal progenitor cells as candidate therapy for retinitis pigmentosa $1,803,768
Early Translational II: leif Havton Repair of Conus Medullaris/Cauda Equina Injury using Human ES Cell-Derived Motor Neurons $1,614,231
SEED Grant: Grant MacGregor Production of Oocytes from Human ES Cells $385,466
SEED Grant: Michelle Khine Micro Platform for Controlled Cardiac Myocyte Differentiation $156,426
SEED Grant: Kyoko Yokomori Derivation and characterization of human ES cells from FSHD embryos $607,200
SEED Grant: Thomas Lane Human Embryonic Stem Cells and Remyelination in a Viral Model of Demyelination $368,081
Research Training II: Peter Donovan UCI-CIRM Research Training Program II $6,540,127
Training Grant I-1: Peter Bryant Stem Cell Research Training Grant $1,935,487
Early Translational III: Craig Walsh Multiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells $4,590,219
New Cell Lines: Leslie Thompson New Cell Lines for Huntington's Disease $1,302,526
Shared Labs: Peter Donovan The University of California: irvine Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course $2,107,376
Disease Team Planning: Leslie Thompson Huntington's Disease Team $41,953
Disease Team Planning: Henry Klassen Stem cells for neuroprotection of photoreceptors in retinitis pigmentosa $23,537
Major Facilities: Michael Drake UC Irvine CIRM Institute $27,156,000
Basic Biology V: Peter Donovan Non-invasive live imaging of stem cell signature metabolic states $540,480
Basic Biology V: Lisa Flanagan Molecular basis of plasma membrane characteristics reflecting stem cell fate potential $994,108
Early Translational IV: Magdalene Seiler Restoring vision by sheet transplants of retinal progenitors and retinal pigment epithelium (RPE) derived from human embryonic stem cells (hESCs) $3,998,948
Disease Team Therapy Development - Research: Henry Klassen Retinal progenitor cells for treatment of retinitis pigmentosa $17,144,825
SEED Grant: Charles Limoli Treating Stress Urinary Incontinence with Human Embryonic Stem Cells $593,242
SEED Grant: Grant MacGregor Derivation and Epigenomic Analysis of hES Cells $385,466
SEED Grant: Grant MacGregor Stem cell therapy on hypertension: A potential source and role of nNOS in brainstem $385,466
SEED Grant: Thomas Lane The role of HER2 signaling in differentiation and maintenance of human embryonic stem cells $368,081
SEED Grant: Kyoko Yokomori Role of RXR in Nurr1-induced Differentiation of Human ES Cells and in Parkinson's Disease $607,200
SEED Grant: Kyoko Yokomori Role of PK2 on the differentiation of human neural stem cells and ischemia-induced neurogenesis $607,200
SEED Grant: Kyoko Yokomori MicroRNAs in Human Embryonic Stem Cell Self-Renewal and Differentiation $607,200
SEED Grant: Brian Cummings Ovol genes and hES differentiation into hair-producing cells $595,345
SEED Grant: Brian Cummings Cell-Cell Interactions Promote Differentiation of Human Embryonic Stem Cells to Insulin-Secreting Cells $595,345
SEED Grant: Brian Cummings Exploring the Therapeutic Potential of Human Embryonic Stem Cells in Pediatric Neurotrauma $595,345
SEED Grant: Thomas Lane Developmental Regulation of Human Embryonic Stem Cells by microRNAs $368,081
SEED Grant: Grant MacGregor 3D_SpineTracker - Automated remyelination detection and classification of axons for sub-acutely injured spinal cord section images for temporal tracking of remyelination after stem cell treatment $385,466
Basic Biology II: Marian Waterman Regulation of Human Thymic Epithelial Cell Development from ESC $1,277,101
Tools and Technologies I: Orhan NALCIOGLU A Multimodality Molecular Imaging Systen (MRSPECT) for in Vivo Stem Cell Tracking $719,798
Tools and Technologies I: Lisa Flanagan Novel Separation of Stem Cell Subpopulations $861,122
Total:
$170,000,209.00
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