Summaries of Review for Applications to RFA 06-02

The following is a listing of all applications reviewed under RFA 06-02 for CIRM Comprehensive Grants. Applications include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Scientific and Medical Research Funding Working Group (SMRFWG) during the review meeting on January 8-10, 2007. A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number.
 
= Recommended for funding
 
= Recommended if funds available
 
= Not Recommended at this time
 
Application Number ICOC Decision Title Scientific Score
RC1-00111-1 Approved Epigenetic gene regulation during the differentiation of human embryonic stem cells: Impact on neural repair 95
RC1-00346-1 Approved Derivation of Inhibitory Nerve Cells from Human Embryonic Stem Cells 90
RC1-00115-1 Approved Molecular and Cellular Transitions from ES Cells to Mature Functioning Human Neurons 89
RC1-00354-1 Approved Prospective isolation of hESC-derived hematopoietic and cardiomyocyte stem cells 89
RC1-00113-1 Approved Constructing a fate map of the human embryo 88
RC1-00359-1 Approved An in vitro and in vivo comparison among three different human hepatic stem cell populations. 87
RC1-00353-1 Approved The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning 87
RC1-00132-1 Approved Chemical Genetic Approach to Production of hESC-derived Cardiomyocytes 85
RC1-00116-1 Approved USING HUMAN EMBRYONIC STEM CELLS TO UNDERSTAND AND TO DEVELOP NEW THERAPIES FOR ALZHEIMER'S DISEASE 85
RC1-00110-1 Approved Improved hES Cell Growth and Differentiation 85
RC1-00100-1 Approved Functional Genomic Analysis of Chemically Defined Human Embryonic Stem Cells 84
RC1-00119-1 Approved Generation of inner ear sensory cells from human ES cells toward a cure for deafness 84
RC1-00131-1 Approved Spinal ischemic paraplegia: modulation by human embryonic stem cell implant. 83
RC1-00104-1 Approved Modeling Myocardial Therapy with Human Embryonic Stem Cells 83
RC1-00148-1 Approved Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells 81
RC1-00137-1 Approved Human oocyte development for genetic, pharmacological and reprogramming applications 79
RC1-00347-1 Approved Understanding hESC-based Hematopoiesis for Therapeutic Benefit 79
RC1-00124-1 Approved Embryonic Stem Cell-Derived Therapies Targeting Cardiac Ischemic Disease 79
RC1-00134-1 Approved Immunology of neural stem cell fate and function 79
RC1-00125-1 Approved MEF2C-Directed Neurogenesis From Human Embryonic Stem Cells 78
RC1-00123-1 Approved Establishment Of Stem Cell Lines From Somatic Cell Nuclear Transfer-Embryos in Humans 77
RC1-00133-1 Approved Guiding the developmental program of human embryonic stem cells by isolated Wnt factors 75
RC1-00135-1 Approved Human stem cell derived oligodendrocytes for treatment of stroke and MS 75
RC1-00151-1 Approved Engineering a Cardiovascular Tissue Graft from Human Embryonic Stem Cells 75
RC1-00149-1 Approved Human Embryonic Stem Cell Therapeutic Strategies to Target HIV Disease 73
RC1-00142-1 Approved microRNA Regulation of Cardiomyocyte Differentiation from Human Embryonic Stem Cells 72
RC1-00108-1 Approved Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC) 69
RC1-00345-1 Approved hESC-Derived Motor Neurons For the Treatment of Cervical Spinal Cord Injury 66
RC1-00144-1 Approved Preclinical Model for Labeling, Transplant, and In Vivo Imaging of Differentiated Human Embryonic Stem Cells 66
RC1-00107-1 -- Controlling Stem Cell Differentiation with GPCR Signals 69
RC1-00356-1 -- ABILITY OF HUMAN ES CELL-DERIVED NEURAL PRECURSORS TO CONTRIBUTE TO AND REPAIR DAMAGED NEURAL CIRCUITS 68
RC1-00145-1 -- Control Mechanisms Governing Human ESC Self Renewal and Differentiation 65
RC1-00114-1 -- hES Differentiation in Lesch Nyhan Disease 64
RC1-00102-1 -- Generation and functional genomic characterization of human embryonic stem cell-derived progenitor cells. 64
RC1-00152-1 -- Dopaminergic Differentiation of Human Embryonic Stem Cells 64
RC1-00101-1 -- IN VIVO REGENERATIVE POTENTIAL OF hESC-DERIVED SKELETAL MYOBLASTS  
RC1-00103-1 -- Factors Regulating Stemness in Human Embryonic Stem Cells  
RC1-00105-1 -- Creating a Human Tumor Micro-environment with Embryonic Stem Cells  
RC1-00106-1 -- Generating Reprogrammed Pluripotent Human Cell Lines Using a Histone Modification Barcode  
RC1-00109-1 -- Chemical and Functional Genomic Approaches toward Understanding hESCs  
RC1-00112-1 -- Intracellular signaling mechanism for control of hESC pluripotency  
RC1-00117-1 -- Interaction between transplanted human embryonic stem cell-derived neuronal precursors and endogenous neurogenesis in ischemic brain  
RC1-00120-1 -- Genome-wide analysis of hormonal systems important for human embryonic stem cell derivation  
RC1-00121-1 -- Human Embryonic Stem Cell Therapy for Myocardial Infarction  
RC1-00122-1 -- Genetic Modification of Human Embryonic Stem Cells  
RC1-00126-1 -- Constructing a library of custom-tailored human embryonic stem cell-derived cardiomyocytes for specific heart therapies  
RC1-00127-1 -- Effect of growth factors on hES cell derivation, growth, and genomic stability  
RC1-00128-1 -- Control of human Embryonic Stem Cell Pluripotence and Fate Choice  
RC1-00129-1 -- Mechanisms of Human Embryonic Stem Cell Self-Renewal  
RC1-00130-1 -- Monitored Systemic Delivery Of HESC to Pathological Organs  
RC1-00136-1 -- Human Embryonic Stem Cell Survival and Transformation  
RC1-00138-1 -- Studying Chromosomal Aneuploidy During Human Embryogenesis Using Human Embryonic Stem Cells Derived From Embryos Characterized by Preimplantation Genetic Diagnosis  
RC1-00139-1 -- Investigation of the mechanism that initiates the molecular heterogeneity in human embryonic stem cells  
RC1-00140-1 -- Derivation and Characterization of hESCs Derived from Single Cleavage-Stage Blastomeres  
RC1-00141-1 -- Functional characterization of the pivotal role of a novel zinc finger protein ZNF206 in regulating early lineage allocation & commitment  
RC1-00146-1 -- Endoderm-specific integration for human embryonic stem cells: towards tissue regenerative solutions for lung and pancreas  
RC1-00147-1 -- DESIGN AND ENGINEERING OF NEURAL STEM CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS FOR REGENERATION AND REPAIR OF MULTIPLE SCLEROSIS  
RC1-00337-1 -- Generation of hNSC lines from hESC: Effect of selective derivation and transplantation niche on cell fate decisions and recovery after SCI  
RC1-00338-1 -- Converting Human Embryonic Stem Cells to Dopamine Neurons for Parkinson's Disease  
RC1-00339-1 -- Human Embryonic Stem Cells for Incurable Skin Diseases and Chronic Wounds  
RC1-00340-1 -- Engineering human embryonic stem cells into ectodermal organs  
RC1-00341-1 -- Building an HIV Resistant Immune System Using Pluripotent Stem Cells  
RC1-00343-1 -- Quantitative time-lapse analysis of pluripotency and trophectoderm differentiation at the single-cell level  
RC1-00344-1 -- Matrix-Assisted hESC Transplantation for Myocardium Stabilization  
RC1-00349-1 -- Embryonic Stem Cell-Derived Hemangioblasts for Hematopoietic Stem Cell Reconstitution  
RC1-00350-1 -- Human Embryonic Stem Cell for Myocardial Restoration  
RC1-00351-1 -- Cryopreservation of Embryonic Progenitors Derived from Human Embryonic Stem Cells  
RC1-00358-1 -- Embryonic stem cell-derived neural stem cells for brain tumor and ALS therapy.  
RC1-00459-1 -- Imaging Human ES-Derived Cells: Defining Parameters for Safety in Regenerative Medicine.  
RC1-00478-1 -- Regulation of Self Renewal and Lineage Commitment in Human Embryonic Stem Cells