Summaries of Review for Applications to RFA 07-02

The following is a listing of all applications reviewed under RFA 07-02 for CIRM New Faculty Awards. Applications include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Grants Working Group (GWG) during the review meeting on October 23-24, 2007. A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number.
 
= Recommended for funding
 
= Recommended if funds available
 
= Not Recommended at this time
 
Application Number ICOC Decision Title Scientific Score
RN1-00577-1 Approved Genetic Encoding Novel Amino Acids in Embryonic Stem Cells for Molecular Understanding of Differentiation to Dopamine Neurons 96
RN1-00561-1 Approved Combinatorial Chemistry Approaches to Develop LIgands against Leukemia Stem Cells 94
RN1-00579-1 Approved Trithorax and Polycomb methyltransferase complexes in cell fate determination. 92
RN1-00527-1 Approved Molecular mechanisms involved in adult neural stem cell maintenance 90
RN1-00566-1 Approved A Novel Engineered Niche to Explore the Vasculogenic Potential of Embryonic Stem Cells 90
RN1-00584-1 Approved Generating pluripotent cell lines from neurons. 90
RN1-00575-1 Approved Genetic dissection of mesodermal commitment to the hematopoietic fates. 88
RN1-00529-1 Approved Noncoding RNAs in Cell Fate Determination 85
RN1-00532-1 Approved Identification of hESC-mediated molecular mechanism that positively regulates the regenerative capacity of post-natal tissues 83
RN1-00564-1 Approved In vitro reprogramming of mouse and human somatic cells to an embryonic state 82
RN1-00525-1 Approved Skeletal muscle development from hESC and its in vivo applications in animal models of muscular dystrophy 80
RN1-00530-1 Approved Molecular mechanisms of neural stem cell differentiation in the developing brain 77
RN1-00544-1 Approved Characterization of mechanisms regulating de-differentiation and the re-acquisition of stem cell identity 77
RN1-00557-1 Approved Mechanisms of Hematopoietic stem cell Specification and Self-Renewal 73
RN1-00562-1 Approved Transcriptional Regulation of Cardiac Pacemaker Cell Progenitors 72
RN1-00572-1 Approved Oral and Craniofacial Reconstruction Using Mesenchymal Stem Cells 69
RN1-00550-1 Approved Epigenetics in cancer stem cell initiation and clinical outcome prediction 61
RN1-00536-1 Approved Reprogramming of human somatic cells back to pluripotent embryonic stem cells 65
RN1-00540-1 Approved Mechanisms of Stem Cell Fate Decisions 65
RN1-00535-1 Approved Bioengineering technology for fast optical control of differentiation and function in stem cells and stem cell progeny 61
RN1-00553-1 -- Mechanisms of NANOG Function in hESC 61
RN1-00549-1 -- Epigenetic determinants of normal and tumor stem cell biology 60
RN1-00537-1 -- Investigation of the Potential of Mouse Embryonic Stem Cells to Develop into Neuroendocrine Cells in Vitro --
RN1-00538-1 Approved ES-Derived Cells for the Treatment of Alzheimer’s Disease 47
RN1-00545-1 -- Neural progenitors and Alzheimer’s disease --
RN1-00554-1 Approved Enhancing Survival of Embryonic Stem Cell-Derived Grafts by Induction of Immunological Tolerance 59
RN1-00528-1 -- Characterization of Immune Responses in Human Embryonic Stem Cells --
RN1-00531-1 -- Inducing human embryonic stem cell differentiation into cardiomyocytes using extracellular matrix cues --
RN1-00534-1 -- Interactions Between Stem Cells and Cartilage in Health and Disease --
RN1-00539-1 -- Directed Stem Cell Recruitment into the CNS in Response to Coxsackievirus Infection --
RN1-00541-1 -- Induction of tolerance in NOD mice using genetically engineered human adipose-derived mesenchymal stem cells --
RN1-00542-1 -- Role of Apolipoprotein E in Hippocampal Neurogenesis and Its Therapeutic Potential in Alzheimer’s Disease --
RN1-00546-1 -- The role of hyaluronan in regulation of differentiation of hESCs in hematopoietic lineage --
RN1-00547-1 -- Stem cell regeneration of neural circuits in murine Huntington’s disease models --
RN1-00551-1 -- Engraftment and Differentiation of Adult Human Stem Cells in Embryonic Eye --
RN1-00552-1 -- Replenishing Dysfunctional Testes with Stem Cells --
RN1-00555-1 -- Building Cardiac Tissue from Stem Cells --
RN1-00558-1 -- Using Stem Cells to Make, Study, and Sort Useful Forebrain Cells --
RN1-00559-1 -- Isolation of Fetal Hepatic Stem Cells for In Utero Transplantation --
RN1-00560-1 -- Identification and functional analysis of stem cells in acute lymphoblastic leukemia --
RN1-00565-1 -- Stem Cell Differentiation in Cytopenias --
RN1-00568-1 -- Designing a microenvironment niche for hepatic differentiation of hESCs --
RN1-00570-1 -- Investigation of the molecular pathways that integrate self-renewal and cell structure in embryonic stem cells. --
RN1-00571-1 -- A novel and generalizable organotypic slice model to evaluate stem cell potential for targeting pediatric brain tumors --
RN1-00573-1 -- Immune Regulation of Retinal Stem Cell Migration and Survival --
RN1-00576-1 -- A novel system for understanding the effects of natural genetic variation and epigenetics of stem cells. --
RN1-00578-1 -- Tumor Neovascularization by a Non-angiogenic Mechanism: Plasticity-based Contributions by Brain Stem Cells. --
RN1-00583-1 -- Developing a transplantation therapy for Parkinson’s disease using hESC-derived dopaminergic neurons. --