Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives.

Journal: 
Adv Mater
Publication Year: 
2011
Authors: 
A Chen , D K Lieu , L Freschauf , V Lew , H Sharma , J Wang , D Nguyen , I Karakikes , R J Hajjar , A Gopinathan , E Botvinick , C C Fowlkes , R A Li , M Khine
Public Summary: 
A substrate for cell culture to create tunable multiscaled alignment "wrinkles" for the functional alignment of human embryonic stem cell derived cardiomyocytes.
Scientific Abstract: 
A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

© 2013 California Institute for Regenerative Medicine