Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.

Journal: 
Chem Commun (Camb)
Publication Year: 
2013
Authors: 
Matthew A Inlay , Veronica Choe , Sophia Bharathi , Nathaniel B Fernhoff , James R Baker , Irving L Weissman , Seok Ki Choi
Public Summary: 
Scientific Abstract: 
We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system.

© 2013 California Institute for Regenerative Medicine