A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants
Monoclonal antibody that targets CD117 and promotes engraftment of hematopoietic stem cells. Could replace toxic conditioning regimens and enable chemotherapy-free transplants. Enabled donor cell HSC engraftment and cure of disease in an animal model of SCID.
Open label, dose escalation trial
Safety. Dosing. Efficacy - HSC engraftment, immune reconstitution.