A Phase I dose escalation and expansion clinical trial of the novel first-in-class Polo-like Kinase 4 (PLK4) inhibitor, CFI-400945 in patients with advanced solid tumors
Solid tumors are the most prevalent form of cancer, and are a major cause of death worldwide. The small molecule being developed inhibits the activity of a protein required in tumor cell lines and cancer stem cells (CSC). It is hypothesized that inhibiting the CSC can prevent tumor regrowth after treatment.
Dose escalation and expansion.
Determination of maximum tolerated dose and recommended Phase 2 dose. Safety. PK. Efficacy in solid cancers.