Progenitor Cells Secreting GDNF for the Treatment of ALS
ALS is a devastating neurodegenerative disease with no cure that specifically affect a patient's motor neurons. This cell therapy intends to support sick motor neurons via astrocyte replacement and pro-survival growth factors. Allogeneic neural stem cells, genetically modified to express GDNF, are injected into the patient spinal cord where they develop into astrocytes.
Dose escalation. Open label.
Safety. Dosing. Efficacy - Lower limb strength