Institution RFA PI Name Award Value University of California, San Diego SEED Grant Catriona Jamieson Derivation and Characterization of Cancer Stem Cells from Human ES Cells $616,305 University of California, San Diego Basic Biology III Farah Sheikh Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC $1,341,955 University of California, San Diego Basic Biology III Kun Zhang Functional characterization of mutational load in nuclear reprogramming and differentiation $1,295,318 University of California, San Diego Basic Biology III Eugene Yeo Neural and general splicing factors control self-renewal, neural survival and differentiation $1,287,619 University of California, San Diego Tools and Technologies II Lawrence Goldstein Developing a method for rapid identification of high-quality disease specific hIPSC lines $1,692,334 University of California, San Diego New Faculty I David Traver Genetic dissection of mesodermal commitment to the hematopoietic fates. $2,150,620 University of California, San Diego Tools and Technologies I Ying Liu Generation of disease models for neurodegenerative disorders in hESCs by gene targeting $709,829 University of California, San Diego Tools and Technologies I Steve Dowdy TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells $720,000 University of California, San Diego Shared Labs Karl Willert Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells $1,737,694 University of California, San Diego Research Training II Sylvia Evans Interdisciplinary Stem Cell Training Program $7,890,588 University of California, San Diego Early Translational III Yang Xu Human ES cell based therapy of heart failure without allogenic immune rejection $1,857,600 University of California, San Diego New Faculty II Benjamin Yu Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins $28,388 University of California, San Diego Shared Labs Karl Willert Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells $1,728,080 University of California, San Diego Research Leadership 12 Eric Ahrens Molecular Imaging for Stem Cell Science and Clinical Application $5,924,428 University of California, San Diego Disease Team Therapy Development III Thomas Kipps Therapeutic Eradication of Cancer Stem Cells $4,179,598 University of California, San Diego Tissue Collection for Disease Modeling Douglas Galasko Collection of skin biopsies to prepare fibroblasts from patients with Alzheimer's disease and cognitively healthy elderly controls $643,693 University of California, San Diego Tissue Collection for Disease Modeling Joseph Gleeson CIRM Tissue Collection for Neurodevelopmental Disabilities $830,428 University of California, San Diego Tissue Collection for Disease Modeling Kang Zhang Generation of fibroblast cell lines in patients with common blinding eye diseases $1,034,425 University of California, San Diego Early Translational III Mark Tuszynski Functional Neural Relay Formation by Human Neural Stem Cell Grafting in Spinal Cord Injury $4,600,447 University of California, San Diego Early Translational I Yang Xu Developing induced pluripotent stem cells into human therapeutics and disease models $5,165,028 University of California, San Diego Comprehensive Grant Martin Marsala Spinal ischemic paraplegia: modulation by human embryonic stem cell implant $2,356,090 University of California, San Diego Comprehensive Grant Lawrence Goldstein Using Human Embryonic Stem Cells to Understand and to Develop New Therapies for Alzheimer's Disease $1,859,414 University of California, San Diego SEED Grant Sylvia Evans Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells $585,600 University of California, San Diego SEED Grant Binhai Zheng Genetic manipulation of human embryonic stem cells and its application in studying CNS development and repair $600,441 University of California, San Diego SEED Grant Cornelis Murre Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells $473,952 University of California, San Diego SEED Grant Anirvan Ghosh Generation of forebrain neurons from human embryonic stem cells $587,591 University of California, San Diego SEED Grant Shu Chien Combinatorial Platform for Optimizing Microenvironments to Control hESC Fate $577,148 University of California, San Diego New Faculty II Shyni Varghese A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment $2,300,569 University of California, San Diego New Faculty II Benjamin Yu Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins $3,017,978 University of California, San Diego New Faculty II Mana Parast Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal $3,078,580 University of California, San Diego Comprehensive Grant Yang Xu Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells $2,467,200 University of California, San Diego New Faculty II Catriona Jamieson Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells $3,065,572 University of California, San Diego New Cell Lines Steve Dowdy Protein transduction of transcription factors: a non-genetic approach to generate new pluripotent cell lines from human skin. $1,073,585 University of California, San Diego Basic Biology III Binhai Zheng Generation and characterization of corticospinal neurons from human embryonic stem cells $1,355,063 University of California, San Diego Basic Biology II Dong-Er Zhang RUNX1 in maintenance, expansion, and differentiation of therapeutic pluripotent stem cells $1,371,540 University of California, San Diego Basic Biology V Cornelis Murre Epigenetic mechanisms that enforce pluripotency in embryonic stem cells $1,161,000 University of California, San Diego Basic Biology II Kun-Liang Guan The function of YAP in human embryonic stem cells $1,245,693 University of California, San Diego Early Translational II Catriona Jamieson Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy $3,103,041 University of California, San Diego Early Translational from Disease Team Conversion Lawrence Goldstein Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $4,139,754 University of California, San Diego Early Translational IV Alysson Muotri A drug-screening platform for autism spectrum disorders using human astrocytes $1,656,456 University of California, San Diego Early Translational II Alysson Muotri Developing a drug-screening system for Autism Spectrum Disorders using human neurons $1,410,697 University of California, San Diego Basic Biology V Wei Wang Systems-level discovery of the regulatory mechanisms directing differentiation of hESC $1,161,000 University of California, San Diego Basic Biology V David Cheresh CD61-driven stemness program in epithelial cancer $1,161,000 University of California, San Diego Basic Biology V Miles Wilkinson New Regulators of Spermatogonial Stem Cells: RHOX Homeobox Transcription Factors $560,160 University of California, San Diego Basic Biology V Maike Sander Defining links between chromatin state and developmental competence $1,050,300 University of California, San Diego Basic Biology V Christian Metallo Metabolic regulation of cardiac differentiation and maturation $1,124,834 University of California, San Diego Basic Biology V Lawrence Goldstein Elucidating pathways from hereditary Alzheimer mutations to pathological tau phenotypes $1,050,300 University of California, San Diego Basic Biology V Dianne McKay Role of intracytoplasmic pattern recognition receptors in HSC engraftment $615,639 University of California, San Diego Disease Team Planning Lawrence Goldstein Human Stem Cell Approaches to Alzheimers Disease Therapies $55,000 University of California, San Diego Basic Biology I Eugene Yeo RNA Binding Protein-mediated Post-transcriptional Networks Regulating HPSC Pluripotency $1,308,901 University of California, San Diego Disease Team Planning Dennis Carson CIRM Planning Grant in Leukemia $52,174 University of California, San Diego Disease Team Research I Dennis Carson Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) $19,999,826 University of California, San Diego Disease Team Research I Lawrence Goldstein Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis $5,694,308 University of California, San Diego New Faculty Physician Scientist Mana Parast Human pluripotent stem cell-based therapeutics for preeclampsia $2,974,750 University of California, San Diego Basic Biology III Charles King Biological relevance of microRNAs in hESC differentiation to endocrine pancreas $1,313,649 University of California, San Diego Basic Biology III Anirvan Ghosh Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells $843,597 University of California, San Diego Basic Biology III Deborah Spector Viral-host interactions affecting neural differentiation of human progenitors $1,372,660 University of California, San Diego Basic Biology III David Cheresh Molecular basis of human ES cell neurovascular differentiation and co-patterning $1,359,996 University of California, San Diego Tools and Technologies II Karl Willert Homologous recombination in human pluripotent stem cells using adeno-associated virus. $1,659,043 University of California, San Diego Tools and Technologies II Shu Chien Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation $1,706,628 University of California, San Diego Transplantation Immunology Yang Xu Induction of immune tolerance to human embryonic stem cell-derived allografts $1,192,680 University of California, San Diego Transplantation Immunology Martin Marsala Induction of immune tolerance after spinal grafting of human ES-derived neural precursors $1,387,800 University of California, San Diego Training Grant I-1 Lawrence Goldstein Interdisciplinary Stem Cell Training Program at UCSD $3,459,396 University of California, San Diego Early Translational III Eugene Yeo Molecules to Correct Aberrant RNA Signature in Human Diseased Neurons $1,532,323 University of California, San Diego Basic Biology IV David Traver DECIPHERING THE INSTRUCTIONS FOR VERTEBRATE HSC SPECIFICATION AND AMPLIFICATION. $1,363,698 University of California, San Diego Basic Biology IV George Sen Regulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases. $1,080,000 University of California, San Diego Basic Biology IV Eugene Yeo Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration $1,260,360 University of California, San Diego Basic Biology IV Ananda Goldrath Mechanisms to protect hESC-derived cells from allogenic immune rejection $1,161,000 University of California, San Diego Basic Biology IV Miles Wilkinson Role of the NMD RNA Decay Pathway in Maintaining the Stem-Like State $1,360,450 University of California, San Diego Basic Biology IV Maike Sander Deciphering transcriptional control of pancreatic beta-cell maturation in vitro $1,258,560 University of California, San Diego Early Translational III Lawrence Goldstein Identifying Drugs for Alzheimer's Disease with Human Neurons Made From Human IPS cells $1,774,420 University of California, San Diego Early Translational III Eric Adler Identification of Novel Therapeutics for Danon Disease Using an iPS Model of the Disease $1,701,575 University of California, San Diego Basic Biology I Karl Willert WNT signaling and the control of cell fate decisions in human pluripotent stem cells. $1,329,298