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University of California, San Diego

Total Awards:

59

ICOC Committed funds:

127 481 042

Awards to the Institution

			Funding
Basic Biology III:	Eugene Yeo	Neural and general splicing factors control self-renewal, neural survival and differentiation	$1,372,660
Basic Biology III:	Deborah Spector	Viral-host interactions affecting neural differentiation of human progenitors	$1,372,660
Basic Biology III:	Anirvan Ghosh	Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells	$1,391,400
Basic Biology III:	Charles King	Biological relevance of microRNAs in hESC differentiation to endocrine pancreas	$1,313,649
Basic Biology III:	Kun Zhang	Functional characterization of mutational load in nuclear reprogramming and differentiation	$1,382,140
Basic Biology III:	Farah Sheikh	Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC	$1,341,955
Basic Biology III:	David Cheresh	Molecular basis of human ES cell neurovascular differentiation and co-patterning	$1,361,448
Basic Biology III:	Binhai Zheng	Generation and characterization of corticospinal neurons from human embryonic stem cells	$1,355,063
New Faculty II:	Shyni Varghese	A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment	$2,300,569
New Faculty II:	Benjamin Yu	Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins	$3,231,649
New Faculty II:	Catriona Jamieson	Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells	$3,065,572
New Faculty II:	Mana Parast	Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal	$3,253,580
New Cell Lines:	Steve Dowdy	Protein transduction of transcription factors: a non-genetic approach to generate new pluripotent cell lines from human skin.	$1,387,800
Tools and Technologies II:	Karl Willert	Homologous recombination in human pluripotent stem cells using adeno-associated virus.	$1,993,586
Tools and Technologies II:	Shu Chien	Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation	$1,832,515
Tools and Technologies II:	Lawrence Goldstein	Developing a method for rapid identification of high-quality disease specific hIPSC lines	$1,816,157
Early Translational II:	Catriona Jamieson	Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy	$3,341,758
Early Translational II:	Alysson Muotri	Developing a drug-screening system for Autism Spectrum Disorders using human neurons	$1,491,471
Basic Biology II:	Dong-Er Zhang	RUNX1 in maintenance, expansion, and differentiation of therapeutic pluripotent stem cells	$1,371,540
Basic Biology II:	Kun-Liang Guan	The function of YAP in human embryonic stem cells	$1,340,565
Disease Team Research I:	Dennis Carson	Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT)	$19,999,826
Disease Team Research I:	Lawrence Goldstein	Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis	$10,857,762
Basic Biology I:	Karl Willert	WNT signaling and the control of cell fate decisions in human pluripotent stem cells.	$1,376,802
Basic Biology I:	Eugene Yeo	RNA Binding Protein-mediated Post-transcriptional Networks Regulating HPSC Pluripotency	$1,376,802
Research Training II:	Sylvia Evans	Interdisciplinary Stem Cell Training Program	$7,890,588
Tools and Technologies I:	Steve Dowdy	TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells	$925,200
Tools and Technologies I:	Ying Liu	Generation of disease models for neurodegenerative disorders in hESCs by gene targeting	$869,262
New Faculty I:	David Traver	Genetic dissection of mesodermal commitment to the hematopoietic fates.	$2,185,369
Shared Labs:	Karl Willert	Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells	$3,711,102
Comprehensive Grant:	Yang Xu	Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells	$2,570,000
			Total: $89,080,450.00

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© 2013 California Institute for Regenerative Medicine