Interdisciplinary Stem Cell Training Program
Interdisciplinary Stem Cell Training Program
Funding Type:
Research Training II
Grant Number:
TG2-01154
Investigator:
Funds Committed:
$7,890,588
Status:
Active
Public Abstract:
This proposal describes a Type I stem cell training program including a School of Medicine, a Division of Biological Sciences, a School of Pharmacy and Pharmaceutical Sciences, and a School of Engineering. This program is designed to provide interdisciplinary training in stem cell biology and medicine by taking advantage of the unique interdisciplinary and inter-institutional environment. A major goal is to train a cadre of young basic and clinical scientists and engineers in the use of quantitative and engineering approaches from the physical sciences such as chemistry, computation, and materials science to make novel discoveries in basic and clinical biomedicine. Basic and clinical science and engineering trainees who complete our program will be ideally suited for future careers as academic or industrial scientists investigating stem cell biology and medicine, or using stem cell based methods to develop new therapeutic approaches to human diseases. Our approach will be to build on each trainee’s specialized foundation of basic or clinical knowledge and provide: •Rigorous education in the principles and applications of embryonic and adult stem cell biology from humans and model organisms •Research training in physical, computational, and engineering methods that can be used to harness stem cells to attack problems of basic and clinical science and their uses to develop new understanding and new therapies •Education in the problems and outlooks associated with the ethical, legal, social, and economic issues associated with stem cell biology Our training program will also serve as a catalyst for the integration of our expanding stem cell biology research and training efforts. Our training is structured to take advantage of the [REDACTED] scientific and medical community by engaging in collaboration with three other institutions. We are requesting financial support for 16 trainees (6 graduate, 5 postdoctoral, 5 clinical fellow).
Statement of Benefit to California:
Benefit of this Program to California This program will benefit the people and the state of California by providing high-quality training in the scientific, clinical, social, and ethical aspects of stem cell research to the scientists and clinicians who will develop and apply future therapies in this rapidly emerging field.
Publications
- Sci Rep (2013) Quantitative Transcriptomics using Designed Primer-based Amplification. (PubMed: 23624976)
- PLoS One (2013) Use of a molecular genetic platform technology to produce human wnt proteins reveals distinct local and distal signaling abilities. (PubMed: 23516471)
- Nat Commun (2013) Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. (PubMed: 23340422)
- Proc Natl Acad Sci U S A (2013) Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. (PubMed: 23324740)
- Proc Natl Acad Sci U S A (2012) Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. (PubMed: 22991473)
- Proc Natl Acad Sci U S A (2012) ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. (PubMed: 23275297)
- Curr Protoc Stem Cell Biol (2012) Dopaminergic differentiation of human pluripotent cells. (PubMed: 22872424)
- Cell Rep (2012) Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche. (PubMed: 23084748)
- Cell Rep (2012) Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche. (PubMed: 23084748)
- Exp Neurol (2012) Stem cells and modeling of autism spectrum disorders. (PubMed: 23036599)
- Cell Rep (2012) Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche. (PubMed: 23084748)
- Annu Rev Cell Dev Biol (2012) LINE-1 Retrotransposition in the Nervous System. (PubMed: 23057747)
- Am J Med Genet A (2012) A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS). (PubMed: 22991235)
- Genes Dev (2012) Wnt signaling: the beta-cat(enin)'s meow. (PubMed: 22279043)
- Genome Med (2012) The expanding world of stem cell modeling of Huntington's disease: creating tools with a promising future. (PubMed: 22943447)
- Cancer Cell (2012) aSIRTing Control over Cancer Stem Cells. (PubMed: 22340585)
- Nat Protoc (2012) Arrayed cellular microenvironments for identifying culture and differentiation conditions for stem, primary and rare cell populations. (PubMed: 22422316)
- Hum Mol Genet (2012) Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. (PubMed: 22437840)
- Eur Cell Mater (2012) Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model. (PubMed: 22665162)
- Nature (2012) A map of the cis-regulatory sequences in the mouse genome. (PubMed: 22763441)
- Proc Natl Acad Sci U S A (2012) beta-Arrestin2 mediates the initiation and progression of myeloid leukemia. (PubMed: 22773819)
- Nature (2012) APJ acts as a dual receptor in cardiac hypertrophy. (PubMed: 22810587)
- Development (2012) A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. (PubMed: 22874919)
- Nature (2012) Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. (PubMed: 22278060)
- Nat Methods (2012) Library-free methylation sequencing with bisulfite padlock probes. (PubMed: 22306810)

