Requests for Applications

Stem Cell Funding Opportunities

All of CIRM's stem cell research funds are given out through direct requests for applications (RFAs). When concepts for new RFAs are approved by the governing board, they are listed below as upcoming RFAs. Once those RFAs are posted and are open for applications, they are listed as Current Requests for Applications. Applications are reviewed by 15 members of the Scientific and Medical Research Funding Working Group (Grants Working Group), who score the grants and provide funding recommendations to the board. Those review reports are posted on this page prior to the meeting in which our governing board votes on which applications to fund.

Related information about CIRM stem cell grants

Upcoming RFAs


Current Requests for Applications

RFA 14-03: CIRM Strategic Partnership IV Awards

The purpose of the Strategic Partnership Awards Initiative (“Initiative”) is to attract industry engagement and investment in CIRM funded stem cell research. The intent of the Initiative is to create incentives and processes that will: (i) enhance the likelihood that CIRM funded projects will obtain funding for future clinical trials (e.g. follow-on financing), (ii) provide a source of co-funding for the earlier stages of clinical development, and (iii) enable CIRM funded projects to access expertise within pharmaceutical and large biotechnology partners in areas such as discovery, preclinical, regulatory, clinical trial design and manufacturing process development.

RFA 14-02: CIRM Preclinical Development I Awards

The purpose of the CIRM Preclinical Development Initiative is to fund early preclinical development activities for Development Candidates (DCs) derived from or targeting stem cells that have compelling and reproducible efficacy in preclinical models of disease or injury, and that are sufficiently well characterized to be ready for the transition from preclinical research to preclinical development. Funding will be provided for the most promising, competitive and successful Development Candidates that CIRM has already invested in at the preclinical research stage, as well as for compelling new projects that are co-funded with matching funds.  

PA 14-01: CIRM Accelerated Development Pathway

The purpose of PA 14-01 is to identify and accelerate high-potential programs that are funded by CIRM to conduct clinical research using a stem cell-based therapeutic, particularly those that may demonstrate clinical proof concept during, or before, the year 2017.  The program will provide selected applicants who are making rapid progress with additional resources and financial support to further accelerate their stem cell-based therapy towards demonstrating evidence of an acceptable safety profile and clinical proof of concept.  Application to PA 14-01 is open only to current CIRM grantees who are already funded to conduct a clinical trial through an active Disease Team Research or Therapy Development award, or a Strategic Partnership award. 

RFA 13-07: CIRM Alpha Stem Cell Clinics Network: Coordinating and Information Management Center

The purpose of RFA 13-07 is to fund a Coordinating and Information Management Center (CIMC) for the CIRM Alpha Stem Cell Clinics (CASC) Network.  The aim of the network is to accelerate therapeutic development of stem cell therapies by providing a high quality, efficient infrastructure to support clinical testing of investigational products, and delivery of approved therapies.   The  Network will be composed of up to five Alpha Stem Cell Clinics Sites (funded by RFA 13-06) and one Coordinating and Information Management Center (CIMC).  The CIMC will support the network by providing consulting services for clinical trial design and operations, provision of public and patient educational services, a resource for data and information management, and healthcare economics expertise to inform clinical trial and reimbursement strategies.

RFA 13-06: CIRM Alpha Stem Cell Clinics Network: Alpha Stem Cell Clinics

The purpose of RFA 13-06 is to fund up to five Alpha Stem Cell Clinics as part of the CIRM Alpha Stem Cell Clinics (CASC) Network.  The goal of the CASC Network is to accelerate therapeutic development of stem cell therapies by providing a high quality, efficient infrastructure to support clinical testing of investigational products, and delivery of approved therapies. The Network will be composed Alpha Stem Cell Clinics Sites and a Coordinating and Information Management Center (funded by RFA 13-07).  The Alpha Stem Cell Clinics will provide critical operational support for the conduct of clinical trials for investigational stem cell therapies and will operate as a center of excellence for approved stem cell therapies.

RFA 13-05: CIRM Tools and Technologies III Awards

The CIRM Tools and Technologies initiative intends to support research that can address regenerative medicine’s unique translational challenges. Tools and Technologies III will support the creation, design and testing of broadly applicable novel tools and technologies and the optimization, improvement, standardization or scale-up of existing tools or technologies for addressing translational bottlenecks to stem cell therapies.

RFA 13-04: External Innovation Pilot Program

The purpose of this RFA is to bring into California the most promising transformative research going on outside the state. CIRM is releasing this RFA as a pilot program. This program would provide funding for key personnel in California to join innovative external studies in order to accelerate those studies towards clinical applications.

PA 12-08: CIRM Patent Assistance Fund Awards

The goal of the Patent Assistance Fund is to ensure adequate prosecution of intellectual property (“IP”) relating to CIRM Funded Inventions (“CFIs”) that have commercial relevance. CIRM’s program is intended to provide funding assistance to help ensure that non-profit Grantees preserve IP positions that are intended to enhance the marketability of CFIs and make downstream investment and development more likely.

PA 08-06: CIRM Conference Grants

This Program Announcement (PA) will support the development and conduct of scientific conferences relevant to stem cell research. A scientific conference is defined as an organized event where persons physically assemble to exchange scientific information or explore a defined scientific subject. Support of such conferences is contingent on the fiscal and programmatic priorities of CIRM. Conference grant awards are open to non-profit organizations in California.

Past requests for applications

RFA 13-03A/B: CIRM Strategic Partnership III Awards 
RFA 13-02: CIRM Basic Biology Awards V
RFA 13-01: CIRM Disease Team Therapy Development III Awards 
RFA 12-09: CIRM Strategic Partnership II Awards
RFA 12-07: CIRM Early Translational IV Research Awards
RFA 12-06: CIRM Stem Cell Genomics Centers of Excellence Awards
RFA 12-05: CIRM Strategic Partnership I Awards
RFA 12-04: CIRM hPSC Repository Award
RFA 12-03: CIRM hiPSC Derivation Award
RFA 12-02: CIRM Tissue Collection for Disease Modeling Awards
RFA 12-01: CIRM New Faculty Physician Scientist Translational Research Awards
RFA 11-04: CIRM Creativity Awards
RFA 11-03: CIRM Basic Biology Awards IV
RFA 11-02: CIRM Early Translational III Research Awards
RFA 10-05: CIRM Disease Team Therapy Development Awards
RFA 10-05: CIRM Disease Team Therapy Development Awards - Part I Planning Award
RFA 10-04: CIRM Basic Biology Awards III
RFA 10-03: CIRM Targeted Clinical Development Awards
RFA 10-02: CIRM Tools and Technologies Awards II
RFA 10-01: CIRM Early Translational II Research Awards
RFA 09-04: CIRM Research Leadership Awards
RFA 09-03: CIRM Stem Cell Transplantation Immunology Awards
RFA 09-02: CIRM Basic Biology Awards II
RFA 09-01: CIRM Disease Team Research Awards
RFA 08-07: CIRM Basic Biology Awards I
RFA 08-05 : CIRM Early Translational Research Awards
RFA 08-04: CIRM Bridges to Stem Cell Research Awards
RFA 08-03: CIRM Research Training Program II
RFA 08-02: CIRM Tools and Technologies Awards
RFA 08-01: CIRM New Faculty Awards II
RFA 07-05: CIRM New Cell Lines Awards
RFA 07-04: CIRM Disease Team Planning Awards
RFA 07-03: CIRM Major Facilities Grant Program
RFA 07-02: CIRM New Faculty Awards
RFA 07-01: CIRM Shared Labs and Stem Cell Techniques Course Grant
RFA 06-02: CIRM Comprehensive Research Grant
RFA 06-01: CIRM SEED Grant
RFA 05-01: CIRM Training Grant

 

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