Bridges to Stem Cell Research
Bridges to Stem Cell Research
We are a large, urban university serving a highly diverse student population. We propose a new stem cell biology training program for master’s-level students in partnership with three leading stem cell research institutions. We propose to offer two new master’s-level specializations in our Biology department to prepare students to enter the stem cell workforce: a Masters of Science in Cell and Molecular Biology with an emphasis in Stem Cell Biology (the “MS program”) in preparation for careers as senior researchers or doctoral studies leading to faculty and research science positions in stem cell biology; and a Professional Science Masters with a concentration in Stem Cell and Regenerative Medicine (the “PSM program”) in preparation for careers as laboratory technicians and research associates. We will recruit and train 10 students each year. Both programs involve core lecture and laboratory courses in developmental, molecular, and cell biology as well as bioethics and scientific writing taught by faculty at our institution who are experts in their field. PSM students will also take business and biotechnology courses while MS students will begin the first six months of their internship in their first year. During the summer after completing their first year of the program, students will participate in a week-long intensive Stem Cell Laboratory course taught by faculty at one of the host sites where students will learn to propagate, maintain, and manipulate human embryonic stem cells. Both programs will provide students with an intensive research experience in stem cell research at one of our host institutions. MS internships will involve 18 months of original stem cell research culminating in a master’s thesis and leading to the preparation of manuscripts for publication. PSM internships will involve 12 months of research training in a stem cell research laboratory, culminating in a final written and oral research report. Mentoring and professional development are an integral part of both programs. Student cohorts will meet monthly with the Program Director (PD) to discuss their academic and research activities. Students will also gain a broader introduction to the importance and application of stem cell research from guest speakers. The PD will meet regularly with the students and their research mentors to provide continuity of programming and ensure that students thrive in their internships. Through its CIRM Bridges to Stem Cell Research program, we will offer a new general education course in Stem Cell Biology and Regenerative Medicine. This course will not only educate a broad audience, but will also provide a mechanism for recruiting students into the stem cell training programs. Thus, CIRM funding will allow our institution to make an important contribution to the stem cell workforce that truly reflects the diverse composition of our state in partnership with three preeminent research institutions.
Statement of Benefit to California:
The proposed CIRM Bridges program will benefit the state of California and its residents by providing training to prepare students to enter research careers in stem cell biology and regenerative medicine. This is particularly important and timely because our state is positioned as a result of the passage of Proposition 71 to become a leader in stem cell research both nationally and globally. With this emerging field it will be crucial to have a skilled workforce equipped to meet the scientific and technical challenges necessary for advancing scientific knowledge and alleviating human suffering. We are extremely well situated to contribute to this effort. Our Biology department has provided training for hundreds of students, those seeking to make career changes as well as those beginning their working lives. We have a long history of educating students in cutting-edge laboratory methods and responding to the needs of industry and academia. Dozens of our graduates have established careers in the sciences, and our alumni are well represented at all levels throughout the region's biotechnology industry. We have a national reputation for contributing to the diversification of the scientific profession through our many training programs which attract, recruit, and support students from groups underrepresented in the sciences, and indeed our student and our faculty are among the most ethnically and culturally diverse in the nation. With the help of our partner institutions, our CIRM Bridges program will expand the training opportunities in our Cell and Molecular Biology program to include two new specializations: stem cell biology, and biotechnology with an emphasis on regenerative medicine. We will provide a comprehensive slate of lab and lecture courses, research internships, professional mentoring, and community service opportunities to ensure that our students possess not only scientific and technical proficiency but also a thorough grasp of the ethical implications of the technology and the ability to communicate effectively with a general as well as a scientific audience. The research internships will provide training in state-of-the-art facilities in the laboratories of three premiere institutions at the forefront of stem cell research, so that students complete the program with the knowledge, skills and experience necessary to work with both federally and non-federally registered stem cell lines. We will also offer a new general education course addressing scientific, humanistic, ethical and legal perspectives on stem cell technology with special presentations open to the general public, and our students will participate in presenting their work to the broader community. Our graduates will be fully prepared to contribute to the growth of a vibrant stem cell industry that is fully reflective of the diversity of backgrounds and perspectives in our state.
Year 1Our CIRM Bridges program serves a highly diverse student population. The CIRM Bridges program funds master-level students that are in either our Masters of Science in Cell and Molecular Biology with an emphasis in Stem Cell Biology (MS program) or our Professional Science Masters with a concentration in Stem Cell and Regenerative Medicine (PSM program). Both programs involve core lecture and laboratory courses in developmental, molecular, and cell biology as well as bioethics and scientific writing taught by faculty who are experts in their field. PSM students will also take business and biotechnology courses while MS students will begin their internship in their first year of the master's program. During the summer after completing their first year of the program, 10 students will be funded with a 12-month CIRM Bridges fellowship. These CIRM fellows will participate in a week-long intensive Stem Cell Laboratory course taught by faculty at an R01 institution where students will learn to propagate, maintain, and manipulate human embryonic stem cells. During the second year of the program, when these students are funded by CIRM, they will focus all of their effort in conducting stem-cell oriented research projects at leading academic and research institutes. Throughout their time in this master's program the student receive academic and research mentorship through individual and group monthly meetings. Upon completion of the program these students are well-prepared to continue their education in PhD or health-related graduate programs as well as enter the biotechnology workforce.
- PLoS One (2013) ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. (PubMed: 23437279)
- Hum Mol Genet (2013) Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. (PubMed: 23077213)
- Endocrinology (2012) Impaired placental nutrient transport in mice generated by in vitro fertilization. (PubMed: 22562173)
- PLoS One (2012) Effect of substrate stiffness on early mouse embryo development. (PubMed: 22860009)
- Brain Res Bull (2012) Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease. (PubMed: 22326483)
- Cell Rep (2012) A resource for the conditional ablation of microRNAs in the mouse. (PubMed: 22570807)
- Addict Biol (2012) Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. (PubMed: 22339852)
- Sci Transl Med (2012) Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. (PubMed: 22972842)
- Stem Cells (2011) Establishment of Human Trophoblast Progenitor Cell Lines from the Chorion. (PubMed: 21755573)
- Anticancer Agents Med Chem (2011) Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond. (PubMed: 21707493)
- Nat Biotechnol (2011) Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. (PubMed: 21490602)
- J Vis Exp (2011) Myo-mechanical analysis of isolated skeletal muscle. (PubMed: 21403622)
- Am J Rhinol Allergy (2010) Nucleic acid extraction efficiency and bacterial recovery from maxillary sinus mucosal samples obtained by brushing or biopsy. (PubMed: 20819463)