Developing a personalized approach to beta cell replacement for patients with a genetic form of diabetes

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Grant Award Details

Grant Number:
DISC1-08868
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Cell Line Generation:
Award Value:
$179,995
Status:
Closed

Progress Reports

Reporting Period:
Year 2

Grant Application Details

Application Title:

Developing a personalized approach to beta cell replacement for patients with a genetic form of diabetes

Public Abstract:
Research Objective

To correct a gene mutation in a patient's stem cells and produce functional replacement cells for the patient to cure their diabetes.

Impact

WE expect that this project can serve as a model for developing new treatments for patients with certain forms of genetic diabetes.

Major Proposed Activities

  • To understand how the patient's gene mutation affects the differentiation, function, and survival of stem cell derived insulin cells
  • To correct the patient's mutation in stem cells, then generate new insulin cells and test if they are fully functional.
Statement of Benefit to California:
California is already a leader in advancing stem cell technology. If we are successful, we believe that California can become the center for patients with certain forms of diabetes to come to for treatment.