Grant Award Details

Developing a personalized approach to beta cell replacement for patients with a genetic form of diabetes
Grant Number: 
DISC1-08868
Project Objective: 
  • To determine the functional requirement for NEUROGENIN3  in the differentiation, maintenance, function, and survival of human pancreatic endocrine cells.

Investigator: 
Type: 
PI
Disease Focus: 
Diabetes
Human Stem Cell Use: 
iPS Cell
Cell Line Generation: 
iPS Cell
Award Value: 
$180,000
Status: 
Active

Grant Application Details

Application Title: 
  • Developing a personalized approach to beta cell replacement for patients with a genetic form of diabetes
Public Abstract: 

Research Objective

To correct a gene mutation in a patient's stem cells and produce functional replacement cells for the patient to cure their diabetes.

Impact

WE expect that this project can serve as a model for developing new treatments for patients with certain forms of genetic diabetes.

Major Proposed Activities

  • To understand how the patient's gene mutation affects the differentiation, function, and survival of stem cell derived insulin cells
  • To correct the patient's mutation in stem cells, then generate new insulin cells and test if they are fully functional.
Statement of Benefit to California: 

California is already a leader in advancing stem cell technology. If we are successful, we believe that California can become the center for patients with certain forms of diabetes to come to for treatment.