Stem Cell Training Program
Stem Cell Training Program
Research Training II
The Stem Cell Training Program includes: experienced, well-funded mentors; essential techniques, methodologies, and facilities relevant to basic, translational, and clinical training in stem cell research; established graduate and training programs that provide the spectrum of training experiences; a clinical enterprise that includes a medical school, teaching hospital, and exceptional infrastructure including a CIRM Shared Research Facility and CIRM Stem Cell Institute; core facilities that provide essential equipment and expertise in stem cell biology and related areas such as animal models, bioengineering, genomics, and imaging; and a clinical program to ensure the translation of bench research to new therapies for human diseases. The program also includes a strong, collaborative framework in which to mentor and cultivate students and young investigators using a team approach. The overarching objective is to provide chosen scholars an integrated experience with state-of-the-art multidisciplinary team training to ensure they become productive, critical thinking, highly trained, and well-rounded collaborative scientists with research careers in stem cell biology and regenerative medicine. This will be accomplished through integration of established campus opportunities and partnering with other related programs and institutions. Faculty from many schools and colleges provide a collaborative structure that has been successful in the current and other funded training programs. Success with the current stem cell training program justifies support for 16 trainees (6 predoctoral, 6 postdoctoral, 4 clinical fellows). Formal training will be provided through mentored research, a didactic curriculum, existing courses in graduate education, established courses that focus on the ethical, legal, and social implications of stem cell research, stem cell biology and regenerative medicine, and a weekly journal club, monthly seminar series with speakers from around the nation, an annual symposium, and an annual training program retreat. The curriculum is designed to bring all scholars and their mentoring teams together throughout the course of the training. The mentors are responsible for selecting and mentoring candidates, evaluating trainee progress, and assisting trainees with career development. The quality of the mentor is a major focus when the selection committee chooses trainees. The leadership of the program spans basic, translational, and clinical research. An Internal Advisory Committee includes the leadership team and representatives from various schools and colleges to oversee the formal process for scholar selection, and expectations for trainees and mentors. Program effectiveness is evaluated through an established educational evaluation program.
Statement of Benefit to California:
The CIRM Stem Cell Training Program will provide significant benefit to the State of California and its citizens in the following ways: • Train diverse scholars to be the next generation of regenerative biomedical science and medicine leaders, advancing basic and clinical translational science as well as mentoring another generation of scholars. • Provide unique shared resources that are used by all stem cell/regenerative medicine scientists and clinicians in California. • Develop team-oriented investigators who will facilitate intra-institutional and inter-institutional research as well as reaching out to industry partners to facilitate and implement new therapies for a host of human diseases. • Educate our community partners about stem cell research including the science as well as the ethical, legal, and social implications of regenerative medicine and stem cell research.
Year 1The UC Davis Stem Cell Training Program includes: (1) experienced, well-funded mentors; (2) essential techniques, methodologies, and facilities relevant to basic, translational, and clinical training in stem cell research; (3) established graduate and training programs that provide the spectrum of experiences in undergraduate, graduate, and postgraduate training, education, and bioethics; (4) a clinical enterprise that includes a medical school, teaching hospital, NIH Clinical and Translational Science Center, and exceptional infrastructure including the CIRM Translational Human Embryonic Stem Cell Shared Research Facility and Institute for Regenerative Cures to support basic, translational, and clinical stem cell/regenerative medicine research; (5) core facilities that provide essential equipment and expertise in cell and molecular biology, in vivo imaging, genomics, animal models, biostatistics and bioinformatics, and Good Manufacturing Practices (GMP), to name a few; (6) a strong, collaborative framework in which to mentor and cultivate students and young investigators using a team approach, with special efforts for underrepresented groups; and (7) community outreach and public education, including advocacy by our leadership council, community advisors, and Scientific Board of Advisors. The overarching objective of our training program is to provide scholars a comprehensive, coordinated, and carefully planned experience with state-of-the-art multidisciplinary team training to ensure they become productive, critical thinking, highly trained, and well-rounded collaborative scientists with research careers in stem cell biology and regenerative medicine. For the current progress report, 9 graduate, 7 postdoctoral fellows, and 3 clinical fellows participated in the program including the weekly journal club, core courses, annual symposia and workshops, and the annual training program retreat. The exceptional science supported during the current reporting period addressed a wide range of research topics and clinical roadblocks.
- PLoS One (2011) Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes. (PubMed: 22110643)
- Acta Biomater (2011) Transferable cell-secreted extracellular matrices enhance osteogenic differentiation. (PubMed: 22079209)
- Stem Cells (2011) Effects on Proliferation and Differentiation of Multipotent Bone Marrow Stromal Cells Engineered to Express Growth Factors for Combined Cell and Gene Therapy. (PubMed: 21898687)
- Tissue Eng Part A (2011) Renal Tissue Engineering with Decellularized Rhesus Monkey Kidneys: Age-Related Differences. (PubMed: 21902603)
- J Neurosci (2011) Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. (PubMed: 21849552)
- PLoS One (2011) Epigenetic Modulation of miR-122 Facilitates Human Embryonic Stem Cell Self-Renewal and Hepatocellular Carcinoma Proliferation. (PubMed: 22140464)
- Curr Top Med Chem (2011) Embryonic Stem Cell-Derived Hematopoietic Stem Cells: Challenges in Development, Differentiation, and Immunogenicity. (PubMed: 21446908)
- Cell Stem Cell (2011) Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches. (PubMed: 21211783)
- Tissue Eng Part A (2011) Characterization and In Vivo Testing of Mesenchymal Stem Cells Derived From Human Embryonic Stem Cells. (PubMed: 21275830)
- Stem Cell Res Ther (2010) Expression of migration-related genes is progressively upregulated in murine Lineage-Sca-1+c-Kit+ population from the fetal to adult stages of development. (PubMed: 20637061)
- Ann Biomed Eng (2010) Design of Experiments Approach to Engineer Cell-Secreted Matrices for Directing Osteogenic Differentiation. (PubMed: 21120695)
- Bioconjug Chem (2010) Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment. (PubMed: 20536174)
- Tissue Eng Part A (2010) Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. (PubMed: 20156112)
- Regen Med (2010) Mesenchymal stem cells for the treatment of neurodegenerative disease. (PubMed: 21082892)