In vitro differentiation of hESCs into corticospinal motor neurons

In vitro differentiation of hESCs into corticospinal motor neurons

Funding Type: 
SEED Grant
Grant Number: 
RS1-00170
Award Value: 
$465,624
Disease Focus: 
Amyotrophic Lateral Sclerosis
Neurological Disorders
Stem Cell Use: 
Embryonic Stem Cell
Status: 
Closed
Public Abstract: 
Statement of Benefit to California: 
Progress Report: 

Year 1

Corticospinal motor neurons are affected in motor neuron diseases and damaged in spinal cord injuries. In this grant application, we proposed to induce human embryonic stem cells to generate corticospinal motor neurons. In this past grant period, we have generated neurons that express the corticospinal motor neuron genes. We are currently characterizing the cell types of theses neurons in detail. In the near future we will transplant them into the brains in mice to test whether they can form functional neural circuits.

Year 2

In the past grant period, we have been continuing to generate brain neurons from cultured human embryonic stems. We have been determining what types of neurons are generated using our protocol. We are testing the functions of these neurons.

© 2013 California Institute for Regenerative Medicine