Download Unit 4

Unit 4: The Immune System and Blood Stem Cell Lineage Tree

By Alexi Weirich, Laurel Barchas, Maria Mouchess, Reviewed by Candice Tahimic

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Suggested time frame:Five to ten class periods

Course level: Advanced Biology, AP/IB level Biology, biotech classes, college level

Inquiry teaching: Read how to modify the curriculum for inquiry teaching

Brief Outline of Unit 4 with download links

I. Invitation: The study of blood Biology

A. Human Blood Observation

1. Microscopic or virtual slides and responses

i. Download Unit Four Appendix A: Human Blood Observation worksheet [pdf]

B. Think, Pair, Share-Connection of body responses to illness

C. The hematopoietic stem cell and its descendents: myeloid, erythroid and lymphoid lineages

1. Students display connection of cell types to proper spot on lineage tree

i. Download Unit Four Appendix B: Hematopoietic Stem Cell Lineage Tree (student worksheet and teacher version)

D. AP extensions of discussion

1. T-cells, stem cells, progenitor cells, mature cell types 

II. Exploration

A. Lecture-The immune system

1. Lymphocyte development, pathogens, immune activation and response-guided lecture
2. Innate and acquired immunity

i. Download Unit Four Appendix C : lecture guide worksheet

3. PowerPoint slides-lineage tree, natural killer cells with webquest or group decision to decide if natural killer cells would be part of nonspecific or specific immunity
4. Cell Tree-lecture connecting natural killer cell to tree
5. Images accompany lecture

III. Application

A. Case studies of blood disorders

1. Jigsaw study of causes and symptoms of HIV/AIDS, sickle cell anemia, leukemia and lymphoma

i. Download Unit Four Appendix D: Blood disorder case studies
Sickle Cell Anemia

2. Jigsaw teaching groups report back explanations of cases. Students record blood disorders summaries on table.

i. Download Unit Four Appendix E: Student Summary Table and Teacher version

B. Bone Marrow Transplant investigation

1. Animations and questions to consider regarding bone marrow transplants
2. Extension of homework activities for topics of bone marrow use and umbilical cord blood
3. Webquest based on topics of blood disorders, hematologists, careers and biomedical research

IV. Assessment

A. Student graphic display of understanding blood diseases
B. Students turn in final copy of their Blood Disorder Summary Table
C. Teacher designs questions to test understanding of lecture topics and concepts of disease causes, symptoms and treatment


© 2013 California Institute for Regenerative Medicine