Induced Pluripotent Stem Cell Repository

The Induced Pluripotent Stem Cell (iPSC) Repository is a major effort from CIRM to create a collection of stem cells developed from thousands of individuals.

CIRM is creating the iPSC bank so that scientists can use the cells, either in a petri dish or transplanted into animals, to study how disease develops and progresses and develop and test new drugs or other therapies. The iPSC bank is now open and cell lines are available at catalog.coriell.org/CIRM.

The large size of the collection will provide researchers with a powerful tool for studying genetic variation between individuals, helping scientists understand how disease and treatment may vary in a diverse population like California’s.

Learn About CIRM's iPSC Repository:

What is the iPSC Repository?
How does it work?
Why iPS cells?
Who is generating the cells?
Which diseases will be represented?
How many samples are being collected for each condition?

What is the iPSC Repository?
The Human Induced Pluripotent Stem Cell (hiPSC) Repository is one of the California stem cell agency’s major efforts to provide valuable resources to the research community. The goal is to create a bank of high quality stem cell lines developed from thousands of individuals for use in research.

How does it work?
Blood or skin samples collected from approximately 3,000 individuals will be turned into stem cell lines. These lines will be made available to researchers throughout California and around the world.

Why iPS cells?
iPS cells are generated from cells easily obtained from living humans, i.e. blood or a small piece of skin; they have unlimited expansion potential in the petri dish, so huge numbers of cells can be generated for research studies or drug development; and they can be coaxed into the types of cells affected in various diseases, such as heart or brain disorders. This provides an unprecedented opportunity to study the cell types from patients that are affected in disease but cannot otherwise be easily obtained in large quantities from them.

Who is generating the cells?
Seven clinician scientists from four California institutions recruit tissue donors who suffer from one of the included diseases or are healthy controls. Some blood or a small piece of skin is collected from those donors, and these samples are shipped to the company Cellular Dynamics International (CDI). CDI generates iPS cells from the samples, and then transfers the iPS cells to the Coriell Institute for Biomedical Research. Coriell operates a cell bank that will distribute the iPS cells to interested researchers at academic and other non-profit institutions, and also to pharmaceutical companies that may want to use them to find new drugs for the diseases that are included in this bank. While CDI and Coriell are located outside California, they have set up facilities at the Buck Institute in Novato, CA, where they generate and bank the iPS cells for this Initiative.

Which diseases will be represented?
The stem cell lines created will represent a variety of diseases or conditions that affect brain, heart, lung, liver or eyes. Grantees come from a variety of California-based institutions:

Principal Investigator Institution Disease Area

Joseph Gleeson

UCSD

Neurodevelopmental Disorders of Children (epilepsy, autism, cerebral palsy)

Joachim Hallmayer

Stanford

Idiopathic Autism

Brigitte Gomperts

UCLA

Idiopathic Pulmonary Fibrosis

Jacquelyn Maher

UCSF

Viral Hepatitis, Nonalcoholic Steatohepatitis

Joseph Wu

Stanford

Cardiomyopathies

Douglas Galasko

UCSD

Alzheimer’s Disease

Kang Zhang

UCSD

Blinding Eye Diseases (age-related macular degeneration, primary open angle glaucoma, diabetic retinopathy)

How many samples are being collected?
Below is a table that outlines CIRM's collection goals for each condition, along with control samples.

Disease Area Number of Disease Samples Number of Control Samples

Neurodevelopmental Disorder of Children (epilepsy, autism, cerebral palsy)

450

200

Autism Spectrum Disorders

200

Cardiomyopathies

650

30

Viral Hepatitis

132

-

Nonalcoholic Steatohepatitis (NASH)

34

20*

Idiopathic Pulmonary Fibrosis

250

 

 

150*

 

 

 

Alzheimer’s Disease

235

Blinding Eye Diseases (age-related macular degeneration, primary open angle glaucoma, diabetic retinopathy)

500

Totals

2451

550

* these control donors will be specifically tested for the absence of lung disease

iPSC Respository in the News:

CIRM's New Stem Cell Bank Up, Running (California Healthline)

Find Out More:

iPSC Repository Brochure [PDF]
Stem Cell FAQ
How do scientists model disease with iPSC's [video]