Protein-engineered injectable hydrogel to improve retention of transplanted adipose-derived stem cells.

Publication Year:

2013

Authors:

Andreina Parisi-Amon, Widya Mulyasasmita, Cindy Chung, Sarah C Heilshorn

PubMed ID:

23184882

Funding Grants:

Preparation and Delivery of Clinically Relevant Numbers of Stem Cells Using 3D Hydrogels

Public Summary:

Improved retention of transplanted stem cells is achieved through minimally invasive delivery in MITCH, a mixing-induced two-component hydrogel that was engineered to possess shear-thinning and self-healing thixotropic properties. MITCH, an ideal injectable cell-delivery vehicle, supports 3D stem-cell culture, resulting in high cell viability and physiologically relevant cell morphology.

Scientific Abstract:

Improved retention of transplanted stem cells is achieved through minimally invasive delivery in MITCH, a mixing-induced two-component hydrogel that was engineered to possess shear-thinning and self-healing thixotropic properties. MITCH, an ideal injectable cell-delivery vehicle, supports 3D stem-cell culture, resulting in high cell viability and physiologically relevant cell morphology.