Biological process activity transformation of single cell gene expression for cross-species alignment.

Publication Year:

2019

Authors:

Hongxu Ding, Andrew Blair, Ying Yang, Joshua M Stuart

PubMed ID:

31653878

Funding Grants:

Center of Excellence for Stem Cell Genomics – UCSC

Public Summary:

The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.

Scientific Abstract:

The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.