Inhibitory interneurons derived from human induced pluripotent stem cells to treat stroke
Grant Award Details
Grant Type:
Grant Number:
DISC2-15137
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$2,140,122
Status:
Active
Grant Application Details
Application Title:
Inhibitory interneurons derived from human induced pluripotent stem cells to treat stroke
Public Abstract:
Research Objective
Allogeneic Human induced pluripotent stem cells-derived inhibitory interneuron therapy product encapsulated in a hyaluronan/VEGF nanoparticle hydrogel for the treatment of stroke
Impact
Previous stem cell-based technologies had poor survival, differentiation, and minimal migration within the peri-infarct brain region and were unable to restore neurological functions after stroke.
Major Proposed Activities
Allogeneic Human induced pluripotent stem cells-derived inhibitory interneuron therapy product encapsulated in a hyaluronan/VEGF nanoparticle hydrogel for the treatment of stroke
Impact
Previous stem cell-based technologies had poor survival, differentiation, and minimal migration within the peri-infarct brain region and were unable to restore neurological functions after stroke.
Major Proposed Activities
- MILESTONE 1: Determine CV-HA-HIPSC-3I efficacy after stroke
- MILESTONE 2: Characterize cellular mechanisms of repair
- MILESTONE 3: Assess neural network function
- MILESTONE 4 - Qualification of cell therapy product
- MILESTONE 5 - Determine Mechanism of Action
Statement of Benefit to California:
The research project proposed in this application will develop a therapy for a disease with no treatment, stroke, that is common and devastating in its consequences. Stroke affects thousands of Californians every year. The intellectual property for this therapy is held by the State of California public university (UCLA) and commercialization will directly benefit the State of California.