Publications by Grantees

The following list of publications describe research carried out with CIRM funding. Click on the publication title for a brief summary of the research and for more information about the CIRM grants that contributed to the research.

Title Year Journal
Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-delta gene. 2014 Am J Physiol Heart Circ Physiol
Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. 2014 Proc Natl Acad Sci U S A
microRNAs and cilia: An ancient connection. 2014 Cell Cycle
miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. 2014 Nature
Modeling hippocampal neurogenesis using human pluripotent stem cells. 2014 Stem Cell Reports
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. 2014 Mol Psychiatry
Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. 2014 Nat Commun
Modular plasmonic nanocarriers for efficient and targeted delivery of cancer-therapeutic siRNA. 2014 Nano Lett
Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. 2014 Cancer Prev Res (Phila)
Mouse liver repopulation with hepatocytes generated from human fibroblasts. 2014 Nature
Mouse SCNT ESCs Have Lower Somatic Mutation Load Than Syngeneic iPSCs. 2014 Stem Cell Reports
Moving beyond surrogate endpoints in cell therapy trials for heart disease. 2014 Stem Cells Transl Med
Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. 2014 Neural Dev
Multiplexed ion beam imaging of human breast tumors. 2014 Nat Med
Murine and human tissue-engineered esophagus form from sufficient stem/progenitor cells and do not require microdesigned biomaterials. 2014 Tissue Eng Part A
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. 2014 J Neurosci
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. 2014 Nat Cell Biol
Nanomicelle formulation modifies the pharmacokinetic profiles and cardiac toxicity of daunorubicin. 2014 Nanomedicine (Lond)
Natural Killer Cell Subsets Differentially Reject Embryonic Stem Cells Based on Licensing. 2014 Transplantation
Neonatal immune-tolerance in mice does not prevent xenograft rejection. 2014 Exp Neurol
Network biology: A compass for stem-cell differentiation. 2014 Nature
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. 2014 Stem Cell Res Ther
Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution. 2014 Future Oncol
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. 2014 Science
Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. 2014 Development
Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. 2014 Stem Cells
Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model. 2014 Proc Natl Acad Sci U S A
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. 2014 Nat Med
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. 2014 Nat Commun
p63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state. 2014 Am J Pathol
Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization of Cardiac Cells. 2014 Methods Mol Biol
Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster. 2014 Cell Rep
Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes. 2014 Cell Death Dis
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. 2014 Mol Psychiatry
Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System. 2014 PLoS Curr
Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. 2014 Nat Neurosci
Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. 2014 Proc Natl Acad Sci U S A
Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway. 2014 Cell Rep
Potential for Cell Therapy in Parkinson’s Disease Using Genetically-Programmed Human Embryonic Stem Cell-Derived Neural Progenitor Cells. 2014 J Comp Neurol
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. 2014 Proc Natl Acad Sci U S A
Primary Cilia Integrate Hedgehog and Wnt Signaling during Tooth Development. 2014 J Dent Res
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. 2014 Cell Stem Cell
Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. 2014 Expert Rev Neurother
Protein post-translational modifications and regulation of pluripotency in human stem cells. 2014 Cell Res
Ptch2 mediates the Shh response in Ptch1-/- cells. 2014 Development
Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. 2014 Nat Immunol
Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. 2014 Nature
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. 2014 Nat Genet
Rapid and Efficient Conversion of Integration-Free Human Induced Pluripotent Stem Cells to GMP-Grade Culture Conditions. 2014 PLoS One
Recombinase-Mediated Reprogramming and Dystrophin Gene Addition in mdx Mouse Induced Pluripotent Stem Cells. 2014 PLoS One
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