Adult stem-like cells exclude “older” mitochondria.

Publication Year:

2015

Authors:

Michael A Teitell

PubMed ID:

25955200

Funding Grants:

A small molecule tool for reducing the malignant potential in reprogramming human iPSCs and ESCs

Public Summary:

Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containing younger mitochondria maintaining the SLC pool.

Scientific Abstract:

Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containing younger mitochondria maintaining the SLC pool.