Adult stem-like cells exclude “older” mitochondria.
Publication Year:
2015
PubMed ID:
25955200
Funding Grants:
Public Summary:
Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containing younger mitochondria maintaining the SLC pool.
Scientific Abstract:
Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containing younger mitochondria maintaining the SLC pool.
