aSIRTing Control over Cancer Stem Cells.

Publication Year:

2012

Authors:

Takahiro Ito, Bryan Zimdahl, Tannishtha Reya

PubMed ID:

22340585

Funding Grants:

Interdisciplinary Stem Cell Training Program at UCSD II

Public Summary:

Cancer stem cells lie at the root of chronic myelogenous leukemia (CML) and mediate its continued growth. Their resistance to current therapies results in an inability to eradicate the disease. In this issue of Cancer Cell, Li et al. identify SIRT1 as a new target for eliminating CML cancer stem cells.

Scientific Abstract:

Cancer stem cells lie at the root of chronic myelogenous leukemia (CML) and mediate its continued growth. Their resistance to current therapies results in an inability to eradicate the disease. In this issue of Cancer Cell, Li et al. identify SIRT1 as a new target for eliminating CML cancer stem cells.