Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo.
Publication Year:
2023
PubMed ID:
37419102
Public Summary:
Innovative approaches to study the complexity of the human brain in a laboratory setting offer exciting opportunities to characterize yet unknown aspects of the human brain function. In this Spotlight article, we highlight recently developed techniques to study microglial cells, the resident immune cells of the brain. Specifically, we discuss how stem cell technology and animal models
Scientific Abstract:
It remains challenging to create a physiologically relevant human-brain-like environment that would support maturation of human pluripotent stem cell (hPSC)-derived microglia (hMGs). Schafer et al.(1) (Cell, 2023) now develop an in vivo neuroimmune organoid model with mature homeostatic hMGs for the study of brain development and disease.