Created of Warm Blood and Nerves: Restoring an Enteric Nervous System in Organoids.

Publication Year:

2017

Authors:

Christopher R Schlieve, Tracy C Grikscheit

PubMed ID:

28061353

Funding Grants:

Mechanism of Tissue Engineered Small Intestine Formation
The generation and expansion of tissue-engineered small intestine from human stem/ progenitor cells: a preclinical study of functional translation
ASCENT- Advanced Stem Cell Enteric Neuropathy Therapy

Public Summary:

The enteric nervous system (ENS) regulates numerous gastrointestinal functions, including epithelial barrier permeability and motility. In a recent Nature Medicine study, Workman et al. (2016) propose a method for introducing human pluripotent stem cell-derived enteric neural crest cells into developing human intestinal organoids, thereby restoring ENS cell types and contractile function.

Scientific Abstract:

The enteric nervous system (ENS) regulates numerous gastrointestinal functions, including epithelial barrier permeability and motility. In a recent Nature Medicine study, Workman et al. (2016) propose a method for introducing human pluripotent stem cell-derived enteric neural crest cells into developing human intestinal organoids, thereby restoring ENS cell types and contractile function.