Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives.

Publication Year:

2011

Authors:

A Chen, D K Lieu, L Freschauf, V Lew, H Sharma, J Wang, D Nguyen, I Karakikes, R J Hajjar, A Gopinathan, E Botvinick, C C Fowlkes, R A Li, M Khine

PubMed ID:

22065428

Funding Grants:

Building Cardiac Tissue from Stem Cells and Natural Matrices

Public Summary:

A substrate for cell culture to create tunable multiscaled alignment "wrinkles" for the functional alignment of human embryonic stem cell derived cardiomyocytes.

Scientific Abstract:

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.