Synthetic surfaces for human embryonic stem cell culture.

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Publication Year:
2010
Authors:
Poornima Kolhar, Venkata Ramana Kotamraju, Sherry T Hikita, Dennis O Clegg, Erkki Ruoslahti
PubMed ID:
20132848
Funding Grants:
Public Summary:
Human embryonic stem cells (hESCs) have numerous potential biomedical applications owing to their unique abilities for self-renewal and pluripotency. Successful clinical application of hESCs and derivatives necessitates the culture of these cells in a fully defined environment. We have developed a novel peptide-based surface that uses a high-affinity cyclic RGD peptide for culture of hESCs under chemically defined conditions.
Scientific Abstract:
Human embryonic stem cells (hESCs) have numerous potential biomedical applications owing to their unique abilities for self-renewal and pluripotency. Successful clinical application of hESCs and derivatives necessitates the culture of these cells in a fully defined environment. We have developed a novel peptide-based surface that uses a high-affinity cyclic RGD peptide for culture of hESCs under chemically defined conditions.