The CIRM Shared Human Embryonic Stem Cell Core Laboratory will provide shared research facilities for use by California scientists. This laboratory will be hosted by a research institution focused on…
Our plan is to establish a ~ 4,700 sq. ft. shared research laboratory dedicated to the experimental manipulation and ultimate clinical application of human embryonic stem cells (hESC). This Shared…
To realize the potential of human embryonic stem cells (hESC) in research and medicine, it is essential to disseminate state of the art technology in this field to the scientific…
We are proposing to expand our “safe haven” human embryonic stem cell laboratory to accommodate the enormous interest in scientific research in this field, and to provide an environment that…
Age-related diseases of the nervous system are major challenges for biomedicine in the 21st century. These disorders, which include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and stroke,…
Human ES (hES) cells offer the opportunity to be converted into replacement tissues for diseased organs and provide cures for diseases like Parkinson’s, diabetes, and a host of neurological disorders.…
GOALS We propose to determine the effects of different forms of apoE on the development of induced pluripotent stem (iPS) cells into functional neurons. In Aim 1, iPS cells will…
Parkinson's disease (PD) is currently the most common neurodegenerative movement disorder, severely debilitating approximately 1-2% of the US population. The disease is caused by a selective loss of dopamine-producing neurons…
The therapeutic use of stem cells depends on the availability of pluripotent cells that are not limited by technical, ethical or immunological considerations. The goal of this proposal is to…
This is an unprecedented time in stem cell biology and regenerative medicine. Today, we have cell lines and tools that did not exist just a few years ago. Indeed, human…
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