CIRM Funded Clinical Trials

Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Before or After Hematopoietic Stem Cell Transplantation (ACES)

Disease Area:

Blood Cancer, Bone Marrow Transplant and Viral Infection

Investigator:

Michael A. Pulsipher

Institution:

Children’s Hospital of Los Angeles

CIRM Grant:

CLIN2-10392 (Active)

Award Value:

$4,825,587.00

Trial Sponsor:

Children's Hospital of Los Angeles

Trial Stage:

Phase 1/2

Trial Status:

Active, not recruiting

Targeted Enrollment:

60

ClinicalTrials.gov ID:

NCT03475212

Details:

Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. A team at Children’s Hospital of Los Angeles is testing the feasibility of providing these immune suppressed patients with engineered T-cells to fight these viruses. Donated virus-specific T-cells will be matched to the patient’s immune system to help boost their ability to fight off these viruses and to provide longer-term anti-viral protection.

Design:

Trial is currently recruiting.