CIRM Funded Clinical Trials

MSC engineered to produce BDNF for the treatment of Huntington’s disease

Disease Area:

Huntington's Disease

Investigator:

Dr. Vicki Wheelock

Institution:

University of California, Davis

CIRM Grant:

DR2A-05415 (Closed)

Award Value:

$8,924,235.00

Trial Sponsor:

The Regents of the University of California, on behalf of its Davis campus

Trial Stage:

Phase 1/2

Trial Status:

Completed

Targeted Enrollment:

29

ClinicalTrials.gov ID:

NCT01937923

Details:

A team at UC Davis plans to use bone marrow derived mesenchymal stem cells to deliver a growth factor, called BDNF, to patients’ brains in order to reduce the death of nerve cells that occurs in Huntington’s Disease (HD). In preparation for such a clinical trial study, the team completed a CIRM-funded observational trial in a group of HD patients to study the progression of disease.

Updates:

This trial is completed.