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Recombinant Bispecific Antibody Targeting Cancer Stem Cells for the Therapy of Glioblastoma

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  • Post published:November 27, 2025
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Glioblastoma multiforme is the most prevalent and aggressive type of brain tumor, and devastating to any patient unfortunate enough to receive its diagnosis. As the most populous state in the…

Continue ReadingRecombinant Bispecific Antibody Targeting Cancer Stem Cells for the Therapy of Glioblastoma

Anti-Notch1, OMP-52M51: A New Cancer Therapeutic to Reduce CSC Frequency

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  • Post published:November 27, 2025
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A important benefit of the tremendous progress in stem cell research has been the recognition that stem cell pathways are frequently re-activated in cancer cells conferring stem cell-like properties on…

Continue ReadingAnti-Notch1, OMP-52M51: A New Cancer Therapeutic to Reduce CSC Frequency

Genetic Re-programming of Stem Cells to Fight Cancer

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  • Post published:November 27, 2025
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Science has made great progress in the treatment of certain cancers with targeted and combination therapies, yet prolonged remissions or cures are rare because most cancer therapies only inhibit cell…

Continue ReadingGenetic Re-programming of Stem Cells to Fight Cancer

Stem cell-based carriers for RCR vector delivery to glioblastoma

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  • Post published:November 27, 2025
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Modified viruses can be used to infect tumor cells and alter the tumor cell to make anti-tumor proteins. Most researchers use virus that can infect and modify the tumor cell…

Continue ReadingStem cell-based carriers for RCR vector delivery to glioblastoma

Dual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication

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  • Post published:November 27, 2025
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Leukemia is the most frequent form of cancer in children and teenagers, but is also common in adults. Chemotherapy has vastly improved the outcome of leukemia over the past four…

Continue ReadingDual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication

Dual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication

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  • Post published:November 27, 2025
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Leukemia is the most frequent form of cancer in children and teenagers, but is also common in adults. Chemotherapy has vastly improved the outcome of leukemia over the past four…

Continue ReadingDual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication

Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy

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  • Post published:November 27, 2025
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Cancer is the leading cause of death for individuals under 85. Relapse and metastatic disease are the leading causes of cancer related mortality. Anti-apoptotic BCL2 family member overexpression has been…

Continue ReadingPreclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy

Niche-Focused Research: Discovery & Development of Hematopoietic Regenerative Factors

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  • Post published:November 27, 2025
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Bone marrow and peripheral blood transplantation utilizing blood stem cells can provide curative treatment for patients with cancers and non-cancerous diseases of the blood and immune systems. Such treatments can…

Continue ReadingNiche-Focused Research: Discovery & Development of Hematopoietic Regenerative Factors

The role of neural stem cells in cerebellar development, regeneration and tumorigenesis

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  • Post published:November 27, 2025
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Stem cells have the remarkable ability to renew themselves and to generate multiple different cell types. This allows them to generate normal tissues during development and to repair tissues following…

Continue ReadingThe role of neural stem cells in cerebellar development, regeneration and tumorigenesis

Epigenetics in cancer stem cell initiation and clinical outcome prediction

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  • Post published:November 27, 2025
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Cancer is responsible for approximately 25% of all deaths in the US and other developed countries. For women, breast and lung cancers and for men, cancers of prostate and lung…

Continue ReadingEpigenetics in cancer stem cell initiation and clinical outcome prediction
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