Disease Focus: Cancer
Development of Therapeutic Antibodies Targeting Human Acute Myeloid Leukemia Stem Cells
Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow that is rapidly fatal within months if untreated. Even with aggressive treatment, including chemotherapy and bone marrow transplantation, five-year overall survival rates range between 30-40%. Evidence indicates that not all cells in this cancer are the same, and that there is a […]
Therapeutic Opportunities To Target Tumor Initiating Cells in Solid Tumors
Cancer is a major cause of human death worldwide. The vast majority of cancer patients suffer from solid tumors whose growth destroys vital organs. We propose to develop novel therapeutic drugs that target solid tumors affecting the brain, colon and ovaries. These cancers account for a significant proportion of currently intractable solid malignancies. Scientists have […]
Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT)
Leukemias are cancers of the blood forming cells that afflict both children and adults. Many drugs have been developed to treat leukemias and related diseases. These drugs are often effective when first given, but in many cases of adult leukemia, the disease returns in a form that is not curable, causing disability and eventual death. […]
Patient’s Stage IV Cancer Vanishes during CIRM-Funded Clinical Trial
This video tells the inspiring story of Tom Howing in his own words. Howing took part in Forty Seven, Inc.’sCIRM-funded clinical trial that’s testing an innovative treatment for cancer. In the two minute video, Howing gives his personal perspective on his cancer diagnosis, the promising but ultimately disappointing results of standard anti-cancer treatments and the remarkable results he’s experienced from […]
Role of Stem Cells on Cognitive Dysfunction after Cancer Therapy
You’d think getting a cancer diagnosis and the subsequent chemo and/or radiation therapy is traumatic enough. But many people receiving cancer therapy also suffer from so-called chemobrain, a condition marked by troubles with memory, attention/concentration, calculations, fine motor skills and other deficits. In this video CIRM grantee and Stanford professor Michelle Monje describes how damage […]
Michael Rothenberg, Stanford – CIRM Stem Cell #SciencePitch
Paul Knoepfler, UC Davis – CIRM Stem Cell #SciencePitch
Amy Sprowles, Humboldt State University – CIRM Stem Cell #SciencePitch
Yi Eve Sun, UCLA – CIRM Stem Cell #SciencePitch 2
Spotlight on Cancer Stem Cells
On December 10, 2009, the CIRM Governing Board heard from Dr. Michael Clarke about cancer stems cells. Dr. Clarke is associate director of the Stanford Institute for Stem Cell and Regenerative Medicine. Robert Klein, chair of the CIRM Governing Board, introduced Clarke. The CIRM-hosted event was presented at Stanford University.