Disease Focus: Infectious Disease
Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-selected CD34+ Cells in AIDS lymphoma patients
Therapeutic Candidate or Device HSC gene modified by a lentiviral vector which encodes a triple combination of HIV-resistance genes and a pre-selective marker. Indication HIV in AIDS-lymphoma patients. Therapeutic Mechanism Bone marrow transplants are standard of care for AIDS-lymphoma patients providing a cure for the patient's lymphoma. A purified population of triple combination anti-HIV lentiviral […]
CMV-specific T cells expressing anti-HIV CAR and CMV vaccine boost as immunotherapy for HIV/AIDS
Therapeutic Candidate or Device Cytomegalovirus (CMV)-reactive T cells that express chimeric antibody receptors (CARs) to recognize and kill HIV-infected cells Indication HIV/AIDS Therapeutic Mechanism Antiretroviral drug therapy (ART) suppresses HIV to undetectable levels but does not eradicate the cellular reservoirs of the virus. We will engineer HIV-specific CAR T cells that will kill reactivated HIV-infected […]
Spotlight on Disease Team Awards – HIV/AIDS: Jeff Sheehy
Spotlight on HIV/AIDS: Jeff Sheehy Jeff Sheehy, spoke at the “Spotlight on Disease Team Awards: HIV/AIDS,” an educational event presented at the CIRM Governing Board meeting on April 29, 2010. Sheehy is communications director at the UCSF AIDS Research Institute and he is a patient advocate member of the CIRM Governing Board. Sheehy was introduced […]
Spotlight on Disease Team Awards – HIV/AIDS: John Zaia
Spotlight on HIV/AIDS: John Zaia John Zaia, M.D., spoke at the “Spotlight on Disease Team Awards: HIV/AIDS,” an educational event presented at the CIRM Governing Board meeting on April 29, 2010. Zaia is the chairman in department of virology and he holds the Aaron D. and Edith Miller Chair for Gene Therapy at the Beckman […]
Spotlight on Disease Team Awards – HIV/AIDS: Loring Leeds
Spotlight on HIV/AIDS: Loring Leeds Loring Leeds, spoke at the “Spotlight on Disease Team Awards: HIV/AIDS,” an educational event presented at the CIRM Governing Board meeting on April 29, 2010. Leeds is a patient advocate and was introduce by John Zaia, M.D., chairman in department of virology at the Beckman Research Institute at the […]