Disease Focus: Intestinal Disease
The First Orally Delivered Cell Therapy for the Treatment of Inflammatory Bowel Disease
Research Objective The goal of this project is to develop the first ORAL cell therapy as a breakthrough treatment for inflammatory bowel disease [IBD]. Impact We engineered a new way to deliver cells ORALLY instead of by injection. In doing so, we will better reach the inflamed tissues and provide a much-needed new treatment for […]
ASCENT- Advanced Stem Cell Enteric Neuropathy Therapy
Translational Candidate ASCENT – Advanced Superdonor Cellular Enteric Neuropathy Therapy, is a donor progenitor cell population that replaces the enteric nervous system. Area of Impact ASCENT would treat enteric neuropathies including Hirschsprung disease and total intestinal aganglionosis which currently have no direct therapy Mechanism of Action Our goal is to develop an allogeneic “off the […]
Inflammatory Bowel Disease and Stem Cell Research – Ophir Klein, UCSF
In his presentation to CIRM’s governing Board, Dr. Ophir Klein, a CIRM grantee and UCSF researcher, detailed his lab’s work to understand how stem cells regulate the healing of the intestine and to eventually find cures for inflammatory bowel disease (IBD).
Living with (IBD) Inflammatory Bowel Disease – Rachel Bonner, Hope for Crohn’s
She doesn’t want your sympathy. She doesn’t want your admiration. She just wants your understanding. Rachel Bonner, a sixteen-year-old high school student and founder of the Hope for Crohn’s charity, spoke to the CIRM’s governing Board on September 10th about what it’s like living with Crohn’s disease.