Disease Focus: Vascular Disease
iPSC-Derived Smooth Muscle Progenitors for Treatment of Abdominal Aortic Aneurysm
Research Objective To assess the therapeutic effect of human induced pluripotent stem cell (iPSC)-derived smooth muscle progenitors (pSMCs) for treatment of abominal aortic aneurysm (AAA). Impact Currently, there are no pharmacologic therapies for AAA. If successful, delivery of autologous pSMCs to the site of AAA will halt or reverse the progression towards a rupture-prone aneurysm. […]
Development of treatments to improve healing of ischemic wounds
Research Objective We aim to develop an angiogenic proteoglycan mimic that will protect tissue from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing. Impact As a treatment, LXW7-DS-SILY combined with a collagen scaffold and EPCs will accelerate healing of ischemic diabetic foot ulcers and reduce limb amputation […]
Injectable pro-regenerative scaffold for treating symptomatic peripheral artery disease
Translational Candidate Injectable biomaterial derived from the natural scaffolding of porcine muscle Area of Impact Improving the quality of life of patients with symptomatic peripheral artery disease. Mechanism of Action The proposed mechanism of action is through recruitment of blood vessels and recruitment and differentiation of muscle stem cells. The injected material forms a new […]
Pulmonary Arterial Hypertension Treated with Cardiosphere-Derived Allogeneic Stem Cells
Therapeutic Candidate or Device CAP-1002 Indication Patients with Pulmonary Arterial Hypertension (PAH) Therapeutic Mechanism CAP-1002's mechanism of action may result in reduced wall thickening of small blood vessels in the lung that are markedly narrowed/obstructed in PAH. The latter results in high resistance against which the right ventricle (RV) must pump in order to drive […]
Cardiovascular Therapies: Spotlight on Stem Cell Research – Welcoming Remarks
Robert Klein, J.D. and Claire Pomeroy, M.D., M.B.A., gave the welcoming remarks for the “Spotlight on Cardiovascular Therapies,” an educational event presented at the California Institute for Regenerative Medicine Governing Board meeting on March 10, 2011 in Burlingame, CA. Klein is Chair of the CIRM Governing Board. Pomeroy is Vice Chancellor for Human Health Sciences […]
Cardiovascular Therapies: Spotlight on Stem Cell Research – Yung-Wei Chi
“Stem Cell Research: Where are we with Peripheral Arterial Disease (PAD)” On March 10, 2011, Yung-Wei Chi, D.O., spoke about a recently launched clinical trial that using a patient’s own stem cells to help prevent amputations due to peripheral arterial disease. Chi is an associate professor of medicine at the UC Davis Vascular Center. Chi […]
Cardiovascular Therapies: Spotlight on Stem Cell Research – Jeanette Owens
“Patient Advocate Speaker” On March 10, 2011, Jeanette Owens spoke about living with peripheral arterial disease and about her hopes for stem cell treatments. Owens was introduced by Claire Pomeroy, M.D., M.B.A., vice chancellor for Human Health Sciences at UC Davis and dean of the UC Davis School of Medicine. Pomeroy is also a member […]