Disease Focus: Vision Loss
Phase 2b Clinical Study of Safety and Efficacy of Intravitreal Injection of Retinal Progenitor Cells (jCell) for Treatment of Retinitis Pigmentosa
Therapeutic Candidate or Device Allogeneic human retinal progenitor cells (hRPC) Indication Retinitis Pigmentosa (RP) Therapeutic Mechanism The cells are intended to remain suspended in the vitreous cavity of the eye and exert a beneficial neurotrophic effect on the degenerating retina. Unmet Medical Need RP is an incurable orphan disease. There are no treatments currently available […]
Clinical Translation of Autologous Regenerative Pluripotent Stem Cell Therapy for Blindness
Therapeutic Candidate or Device The therapeutic candidate is a patient specific (autologous) induced pluripotent stem cell derived retinal pigment epithelium (AiPSC-RPE) product. Indication AiPSC-RPE cell product will be indicated for the treatment of maculopathies related to RPE atrophy. Therapeutic Mechanism The proposed therapy is an autlogous cell product and intended to be used as a […]
Regeneration of a Normal Corneal Surface by Limbal Stem Cell Therapy
Therapeutic Candidate or Device cultivated patient-specific corneal epithelial stem cells (limblal stem cells, LSC) Indication Corneal blindness from inability to heal due to corneal epithelial stem cell deficiency as a results of injury Therapeutic Mechanism Limbal stem cell deficiency (LSCD) leads to inability to heal. The most desired treatment is to replace the necessary amount […]
IND-enabling study of subretinal delivery of human neural progenitor cells for the treatment of retinitis pigmentosa
Therapeutic Candidate or Device human fetal cortex derived neural progenitor cells (CNS10-NPC) Indication To stabilize disease progression and maintain ocular integrity and vision for RP patients. This approach can be applied to more prevalent AMD. Therapeutic Mechanism A single subretinal injection of Human neural progenitor cells (CNS10-NPC) offers dramatic preservation of vision. CNS10-NPC engraft and […]
Stem Cell Clinical Trial for Retinitis Pigmentosa: Rosie’s Story
Rosie Barrero has been steadily losing her vision since childhood due to retinitis pigmentosa (RP), an inherited, incurable disease. In 2016, she volunteered for a CIRM-funded clinical trial testing the use of stem cells to restore her vision. In this video, Rosie tells her RP story. SeeĀ our Disease Fact Sheet on blindness for more information […]
Eyeing Stem Cell Therapies for Vision Loss
Stem Cells in Your Face, Episode 3: Eyeing Stem Cell Therapies for Vision Loss. Written and narrated by Kevin McCormack. Directed and edited by Todd Dubnicoff. Eye anatomy animations by InfoShots.com. Additional graphics by Todd Dubnicoff. More than seven million people in the US struggle to see. While most are not completely blind, they have […]
Masayo Takahashi – 2015 Winner of Ogawa-Yamanaka Stem Cell Prize
Dr Masayo Takahashi from the RIKEN center in Japan received the prestigious 2015 Ogawa-Yamanaka Prize for developing a human induced pluripotent stem (iPS) cell therapy to treat a debilitating eye disease called macular degeneration. The Prize was presented by the Gladstone Institutes in San Francisco.
A Stem Cell-Based Clinical Trial for Retinitis Pigmentosa: Henry Klassen, UC Irvine
Retinitis pigmentosa (RP) is a genetic disease that gradually destroys the light sensing nerve cells, called photoreceptors, located in the retina at the back of the eye. In this video, UC-Irvine professor Henry Klassen describes a CIRM-funded project that aims to begin a stem cell-based clinical trial for RP in early 2015. See our fact […]
A Stem Cell-Based Therapy for Retinitis Pigmentosa: The Patient’s Perspective
Retinitis pigmentosa (RP) is a genetic disease that gradually destroys the light sensing nerve cells, called photoreceptors, located in the retina at the back of the eye. In this video, Rosalinda and German Barrero speak about the devastating impact of RP on their lives and their excitement about a soon to begin CIRM-funded stem cell-based […]