All CIRM Grants

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Institution Researcher name Grant Type Grant Title Award Value
University of California, San Francisco Mort Cowan Clinical Trial Stage Projects Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells $12,000,000
University of California, Los Angeles Dr. Steven M. Dubinett MD Clinical Trial Stage Projects A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC $10,955,315
Medeor Acquisition Corp. Daniel Brennan Clinical Trial Stage Projects Cellular Immunotherapy for Induction of Immune Tolerance in HLA Matched Living Donor Kidney Transplant Recipients $11,217,155
Poseida Therapeutics, Inc. Rajesh Belani MD Clinical Trial Stage Projects Clinical Study of T stem cell memory (Tscm)-based CAR-T cells in Patients with Multiple Myeloma $19,813,407
Children’s Hospital of Los Angeles Michael A. Pulsipher Clinical Trial Stage Projects Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Before or After Hematopoietic Stem Cell Transplantation (ACES) $4,825,587
Calibr Dr. Kristen A Johnson Clinical Trial Stage Projects Evaluation of the Safety and Tolerability of KA34 in a Phase 1, Double-Blind, Dose Escalation Trial in Patients with Knee Osteoarthritis $8,447,523
Angiocrine Bioscience, Inc. Dr. Edward Kavalerchik Clinical Trial Stage Projects AB-110-001 Phase 1b Trial and Related Activities to Support Clinical Development of AB-110 $5,000,000
SanBio, Inc. Dr. Bijan Nejadnik Clinical Trial Stage Projects A Double-Blind, Controlled Ph 2b Study of the Safety and Efficacy of Modified Stem Cells in Patients with Chronic Motor Deficit from Ischemic Stroke $18,970,000
City of Hope, Beckman Research Institute Dr. Christine E. Brown Clinical Trial Stage Projects Phase I Study of Chimeric Antigen Receptor Engineered Central Memory T cells for the Treatment of Malignant Glioma $12,753,854
University of California, San Diego Thomas J Kipps Clinical Trial Stage Projects A Phase 1b/2a Study of the ROR1-Targeting Monoclonal Antibody, Cirmtuzumab, and the Bruton Tyrosine Kinase Inhibitor, Ibrutinib, in B-Cell Cancers $18,292,674
Forty Seven Inc. Mark Chao Clinical Trial Stage Projects Phase 1b Trial of Hu5F9-G4 Monotherapy or Hu5F9-G4 in Combination with Azacitidine in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome $0
BrainStorm Cell Therapeutics Dr. Ralph Kern Clinical Trial Stage Projects A Phase 3, Randomized, Placebo-controlled Multicenter Study to Evaluate Efficacy & Safety of Repeated Administrations of NurOwn® in Patients with ALS $15,912,390
Caladrius Biosciences Dr. William Sietsema Clinical Trial Stage Projects Phase 2 Safety and Efficacy Study of CLBS03 Autologous T-Regulatory Cells in Adolescents with Recent Onset Type 1 Diabetes Mellitus $8,175,946
jCyte, Inc Henry John Klassen Clinical Trial Stage Projects Phase 2b Clinical Study of Safety and Efficacy of Intravitreal Injection of Retinal Progenitor Cells (jCell) for Treatment of Retinitis Pigmentosa $8,295,750
Humacyte, Inc. Jeffrey Lawson Clinical Trial Stage Projects A Phase 3 Study Comparing the Utility of Human Acellular Vessels to Arteriovenous Fistula in Subjects with End-Stage Renal Disease (California Sites) $3,525,000
ViaCyte, Inc. Manasi Jaiman Clinical Trial Stage Projects Clinical trial of directly vascularized islet cell replacement therapy for high-risk type 1 diabetes $13,607,002
Forty Seven Inc. Mark Chao Clinical Trial Stage Projects A Phase 1b/2 Trial of the Anti-CD47 Antibody Hu5F9-G4 in Combination with Cetuximab in Patients with Solid Tumors and Advanced Colorectal Cancer $0
Nohla Therapeutics Inc Dr. Colleen Delaney Clinical Trial Stage Projects A Phase 2 Open-Label, Multi-Center, Randomized, Controlled, Optimal Dose-Finding Study of DCC-UCB in Adults Receiving High Dose Chemotherapy for AML $4,310,000
St. Jude Children’s Research Hospital Stephen Gottschalk Clinical Trial Stage Projects Lentiviral Gene Therapy for Infants with X-linked Severe Combined Immunodeficiency using Autologous Bone Marrow Stem Cells and Busulfan Conditioning $5,118,785
Cedars-Sinai Medical Center Dr. Michael I Lewis Clinical Trial Stage Projects Pulmonary Arterial Hypertension Treated with Cardiosphere-Derived Allogeneic Stem Cells $7,354,772
Stanford University Dr Robert Lowsky Clinical Trial Stage Projects Induction of Tolerance to Combined Kidney and Hematopoietic Progenitor Cell Transplants from HLA Haplotype Matched Living Donors $6,653,266
University of California, Los Angeles Dr. Donald B. Kohn PhD Clinical Trial Stage Projects Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS lentiviral vector encoding for human ADA gene in ADA-SCID subjects $5,827,000
Orchard Therapeutics plc Leslie Meltzer Clinical Trial Stage Projects Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS lentiviral vector encoding for human ADA gene in ADA-SCID subjects $2,638,745
University of California, Los Angeles Dr. Donald B Kohn Clinical Trial Stage Projects Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS lentiviral vector encoding for human ADA gene in ADA-SCID subjects $10,156,925
Cedars-Sinai Medical Center Professor Clive Niels Svendsen Clinical Trial Stage Projects Human Neural Progenitors Secreting Glial Cell Line-Derived Neurotrophic Factor (CNS10-NPC-GDNF) for the Treatment of Amyotrophic Lateral Sclerosis $6,154,067
University of California, San Francisco Dr. Tippi C. MacKenzie MD Clinical Trial Stage Projects In Utero Hematopoietic Stem Cell Transplantation For The Treatment Of Fetuses With Alpha Thalassemia Major $9,350,000
Humacyte, Inc. Jeffrey Lawson Clinical Trial Stage Projects A Human Acellular Vessel in Patients Needing Renal Replacement Therapy: A Comparison with ePTFE Grafts as Conduits for Hemodialysis (HUMANITY) $7,625,000
Capricor, Inc Dr. Linda Marban Clinical Trial Stage Projects Allogeneic Cardiosphere-Derived Cells for Duchenne Muscular Dystrophy Cardiomyopathy $3,376,259
University of California, Davis Dr Mehrdad Abedi Clinical Trial Stage Projects Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-selected CD34+ Cells in AIDS lymphoma patients $8,414,265
ImmunoCellular Therapeutics Anthony J. Gringeri Clinical Trial Stage Projects A Phase III randomized double-blind, controlled study of ICT 107 with maintenance temozolomide (TMZ) in newly diagnosed glioblastoma following resection and concomitant TMZ chemoradiotherapy $5,391,016
Caladrius Biosciences Robert Dillman Clinical Trial Stage Projects Tumor stem cell-targeted immunotherapy for metastatic melanoma –a randomized phase 3 clinical trial. $3,000,000
University of California, Los Angeles Dr. Donald B. Kohn PhD Clinical Trial Stage Projects A Phase I/II, Non Randomized, Multicenter, Open-Label Study of G1XCGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease $7,083,364
Rejuvenate Bio Deborah D. Ascheim Late Stage Preclinical Projects Novel Gene Therapy Targeting Multiple Pathological Drivers of Desmoplakin Associated Arrhythmogenic Cardiomyopathy $4,000,000
University of California, San Diego Mark H Tuszynski Late Stage Preclinical Projects Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI) $6,000,000
University of California, Los Angeles Dr. Arjun Deb Late Stage Preclinical Projects Development of a therapeutic monoclonal antibody for the treatment of myocardial infarction and heart failure $5,999,998
Children’s Hospital of Los Angeles Shahab Asgharzadeh Late Stage Preclinical Projects Chimeric TGFB Signaling Receptor (CTSR) Enabled Anti-B7H3 CAR T-cell Therapy in Children and AYA with Recurrent Solid Tumors $6,000,000
University of California, San Francisco Thomas Martin Late Stage Preclinical Projects A 1XX-enhanced and fully non-viral BCMA CAR T cell therapy for Relapsed and Refractory Multiple Myeloma (UCCT-BCMA-1) $4,585,501
Elpida Therapeutics Mr Terry Pirovolakis Late Stage Preclinical Projects Pre-Clinical To Clinical Gene Therapy Development For CMT4J $3,930,964
AcuraStem Incorporated Mr. Samuel V. Alworth MS, MBA Late Stage Preclinical Projects Manufacturing of AS-202, an Antisense oligonucleotides for a Phase 1/2 Clinical Trial for Amyotrophic Lateral Sclerosis $0
Cedars-Sinai Medical Center Dr. Eugenio Cingolani Late Stage Preclinical Projects Extracellular Vesicles for Ventricular Tachycardia $5,999,441
City of Hope, Beckman Research Institute Prof. Karen S Aboody M.D. Late Stage Preclinical Projects Neural stem cell delivered CRAd-S-pk7 oncolytic viro-immunotherapy for ovarian cancer $5,314,547
Tr1X Inc. Dr. Maria Grazia Roncarolo Late Stage Preclinical Projects TRX103 for prevention of GvHD in patients receiving HLA mismatched related or unrelated allogeneic HSCT for the treatment of hematologic malignancies. $4,000,000
Mahzi Therapeutics Dr. Yael Weiss Late Stage Preclinical Projects Development of a Gene Therapy for the Treatment of WWOX related epileptic encephalopathy (WOREE) $4,000,000
University of California, Davis Dr Mehrdad Abedi Late Stage Preclinical Projects Superior forward-oriented b-globin vector for treating Sickle Cell Disease $4,598,398
Stanford University Dr. Matthew H Porteus Late Stage Preclinical Projects Autologous Gene Corrected Sinus Basal Cells to Treat Serious Cystic Fibrosis Sinus Disease $6,000,000
University of California, Irvine Kyriacos A Athanasiou Late Stage Preclinical Projects Treatment of the TMJ disc complex $6,000,000
Aspera Biomedicines, Inc. Catriona Jamieson Late Stage Preclinical Projects Cancer Stem Cell Interception with Rebecsinib: A First-in-Class ADAR1 Inhibitor $3,200,000
University of California, Los Angeles Dr. Jerome A. Zack Ph.D. Late Stage Preclinical Projects Clinical Translation of Autologous Regenerative Pluripotent Stem Cell Therapy for Blindness $6,000,000
Kenai Therapeutics Howard J Federoff Late Stage Preclinical Projects Allogeneic iPSC derived Dopaminergic Drug Product for Parkinson’s disease $4,000,000
Rampart Bioscience Jeffrey Bartlett Late Stage Preclinical Projects Ex vivo Engineering of Autologous Hematopoietic Stem Cells for the Treatment of Hypophosphatasia $3,999,980
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