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Grant Type
Grant Title
Award Value
City of Hope, Beckman Research Institute
Dr Saul J Priceman
Clinical Trial Stage Projects
A Phase I Study of Chimeric Antigen Receptor Engineered Stem/Memory T Cells for the Treatment of HER2-Positive Brain Metastases
$9,015,149
University of California, San Diego
Dr. Stephanie Cherqui
Clinical Trial Stage Projects
Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis.
$11,999,944
jCyte, Inc
Henry John Klassen
Clinical Trial Stage Projects
A Phase 2 Study of the Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects with Retinitis Pigmentosa
$5,175,000
University of California, San Francisco
Peter Stock
Clinical Trial Stage Projects
Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Diabetes in the Intra-Muscular Site: PARADIGM
$11,083,012
Jasper Therapeutics, Inc.
Wendy Pang
Clinical Trial Stage Projects
A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants
$2,313,398
Stanford University
Dr. Everett H. Meyer
Clinical Trial Stage Projects
Induction of Tolerance by Combinatorial Therapy w/ Donor Stem Cells and Expanded Recipient Treg cells in HLA-mismatched Kidney Transplant Recipients
$11,955,585
City of Hope, Beckman Research Institute
Dr. De-Fu Zeng
Clinical Trial Stage Projects
Treatment of sickle cell disease by induction of mixed chimerism and immune tolerance using CD4+ T-depleted haploidentical blood stem cell transplant
$4,352,180
University of California, San Francisco
Mort Cowan
Clinical Trial Stage Projects
Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells
$12,000,000
University of California, Los Angeles
Dr. Steven M. Dubinett MD
Clinical Trial Stage Projects
A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC
$10,955,315
Medeor Acquisition Corp.
Daniel Brennan
Clinical Trial Stage Projects
Cellular Immunotherapy for Induction of Immune Tolerance in HLA Matched Living Donor Kidney Transplant Recipients
$11,217,155
Children’s Hospital of Los Angeles
Michael A. Pulsipher
Clinical Trial Stage Projects
Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Before or After Hematopoietic Stem Cell Transplantation (ACES)
$4,825,587
jCyte, Inc
Henry John Klassen
Clinical Trial Stage Projects
Phase 2b Clinical Study of Safety and Efficacy of Intravitreal Injection of Retinal Progenitor Cells (jCell) for Treatment of Retinitis Pigmentosa
$8,295,750
Stanford University
Dr Robert Lowsky
Clinical Trial Stage Projects
Induction of Tolerance to Combined Kidney and Hematopoietic Progenitor Cell Transplants from HLA Haplotype Matched Living Donors
$6,653,266
University of California, Los Angeles
Dr. Donald B. Kohn PhD
Clinical Trial Stage Projects
Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS lentiviral vector encoding for human ADA gene in ADA-SCID subjects
$5,827,000
University of California, San Francisco
Dr. Tippi C. MacKenzie MD
Clinical Trial Stage Projects
In Utero Hematopoietic Stem Cell Transplantation For The Treatment Of Fetuses With Alpha Thalassemia Major
$9,350,000
University of California, Davis
Dr Mehrdad Abedi
Clinical Trial Stage Projects
Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-selected CD34+ Cells in AIDS lymphoma patients
$8,414,265
University of California, Los Angeles
Dr. Donald B. Kohn PhD
Clinical Trial Stage Projects
A Phase I/II, Non Randomized, Multicenter, Open-Label Study of G1XCGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease
$7,083,364
Rejuvenate Bio
Deborah D. Ascheim
Late Stage Preclinical Projects
Novel Gene Therapy Targeting Multiple Pathological Drivers of Desmoplakin Associated Arrhythmogenic Cardiomyopathy
$4,000,000
University of California, San Diego
Mark H Tuszynski
Late Stage Preclinical Projects
Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI)
$6,000,000
University of California, Los Angeles
Dr. Arjun Deb
Late Stage Preclinical Projects
Development of a therapeutic monoclonal antibody for the treatment of myocardial infarction and heart failure
$5,999,998
University of California, San Francisco
Thomas Martin
Late Stage Preclinical Projects
A 1XX-enhanced and fully non-viral BCMA CAR T cell therapy for Relapsed and Refractory Multiple Myeloma (UCCT-BCMA-1)
$4,585,501
Children’s Hospital of Los Angeles
Shahab Asgharzadeh
Late Stage Preclinical Projects
Chimeric TGFB Signaling Receptor (CTSR) Enabled Anti-B7H3 CAR T-cell Therapy in Children and AYA with Recurrent Solid Tumors
$6,000,000
Elpida Therapeutics
Mr Terry Pirovolakis
Late Stage Preclinical Projects
Pre-Clinical To Clinical Gene Therapy Development For CMT4J
$3,930,964
Cedars-Sinai Medical Center
Dr. Eugenio Cingolani
Late Stage Preclinical Projects
Extracellular Vesicles for Ventricular Tachycardia
$5,999,441
City of Hope, Beckman Research Institute
Prof. Karen S Aboody M.D.
Late Stage Preclinical Projects
Neural stem cell delivered CRAd-S-pk7 oncolytic viro-immunotherapy for ovarian cancer
$5,314,547
Mahzi Therapeutics
Dr. Yael Weiss
Late Stage Preclinical Projects
Development of a Gene Therapy for the Treatment of WWOX related epileptic encephalopathy (WOREE)
$4,000,000
Tr1X Inc.
Dr. Maria Grazia Roncarolo
Late Stage Preclinical Projects
TRX103 for prevention of GvHD in patients receiving HLA mismatched related or unrelated allogeneic HSCT for the treatment of hematologic malignancies.
$4,000,000
University of California, Irvine
Kyriacos A Athanasiou
Late Stage Preclinical Projects
Treatment of the TMJ disc complex
$6,000,000
Stanford University
Dr. Matthew H Porteus
Late Stage Preclinical Projects
Autologous Gene Corrected Sinus Basal Cells to Treat Serious Cystic Fibrosis Sinus Disease
$6,000,000
Aspera Biomedicines, Inc.
Catriona Jamieson
Late Stage Preclinical Projects
Cancer Stem Cell Interception with Rebecsinib: A First-in-Class ADAR1 Inhibitor
$3,200,000
University of California, Los Angeles
Dr. Jerome A. Zack Ph.D.
Late Stage Preclinical Projects
Clinical Translation of Autologous Regenerative Pluripotent Stem Cell Therapy for Blindness
$6,000,000
Rampart Bioscience
Jeffrey Bartlett
Late Stage Preclinical Projects
Ex vivo Engineering of Autologous Hematopoietic Stem Cells for the Treatment of Hypophosphatasia
$3,999,980
Kenai Therapeutics
Howard J Federoff
Late Stage Preclinical Projects
Allogeneic iPSC derived Dopaminergic Drug Product for Parkinson’s disease
$4,000,000
Nammi Therapeutics, Inc.
Dr. David R Stover
Late Stage Preclinical Projects
IND-Enabling activities for the masked immunocytokine, QXL138AM
$3,999,113
Calidi Biotherapeutics, Inc.
8587949607 Boris Minev
Late Stage Preclinical Projects
Allogeneic mesenchymal stem cells loaded with oncolytic virus for cancer treatment
$3,111,467
University of California, Davis
Dr. Joseph S Anderson
Late Stage Preclinical Projects
Hematopoetic stem cell gene therapy for the treatment of Tay-Sachs disease
$4,048,253
Ossium Health, Inc.
Dr. Brian Johnstone
Late Stage Preclinical Projects
Development of OSSM-007, cryopreserved interferon-gamma primed allogeneic MSCs, for treatment of steroid refractory acute graft versus host disease
$3,457,858
Stanford University
Natalia Gomez-Ospina
Late Stage Preclinical Projects
Genome Editing of Autologous Hematopoietic Stem Cells to Treat Severe Mucopolysaccharidosis type 1 (Hurler Syndrome)
$5,444,353
University of California, San Francisco
Dr. Karin Lindgren Gaensler
Late Stage Preclinical Projects
Development of TriLeukeVax, an Engineered Autologous Leukemia Vaccine for Stimulating Cytolytic Immune Responses to Residual Leukemic Stem Cells
$6,000,000
University of California, Los Angeles
Dr. Antoni Ribas MD/PhD
Late Stage Preclinical Projects
Skin regeneration and wound healing with a topical BRAF inhibitor
$5,005,126
ImmunoVec
Dr. Ryan L. Wong
Late Stage Preclinical Projects
Hematopoietic Stem Cell Gene Therapy for XCGD
$3,999,959
University of Southern California
Dr. Denis A Evseenko Dr.
Late Stage Preclinical Projects
Plurocart: a novel stem cell-based implant for articular cartilage restoration
$5,999,782
University of California, San Diego
Thomas J Kipps
Late Stage Preclinical Projects
Late Stage Pre-Clinical Development of a Cirmtuzumab Based CAR T-cell for the Treatment of ROR1+ Hematological Malignancies
$2,160,000
City of Hope, Beckman Research Institute
Dr. Angelo Manuel Almeida Cardoso Ph.D., MD
Late Stage Preclinical Projects
Ex Vivo Gene Engineering of Blood Stem Cells for Enhanced Chemotherapy Efficacy in Glioblastoma Patients
$3,684,259
University of California, Irvine
Dr. Leslie M Thompson
Late Stage Preclinical Projects
An hESC-derived hNSC Therapeutic for Huntington’s Disease
$5,635,393
University of California, Los Angeles
Dr. Donald B. Kohn PhD
Disease Team Therapy Development III
Clinical Trial of Stem Cell Gene Therapy for Sickle Cell Disease
$13,145,465
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