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Institution Researcher name Grant Type Grant Title Award Value
City of Hope, Beckman Research Institute Dr Saul J Priceman Clinical Trial Stage Projects A Phase I Study of Chimeric Antigen Receptor Engineered Stem/Memory T Cells for the Treatment of HER2-Positive Brain Metastases $9,015,149
University of California, San Diego Dr. Stephanie Cherqui Clinical Trial Stage Projects Phase 1/2 study for autologous human CD34+ hematopoietic stem cells ex vivo transduced with pCCL-CTNS lentiviral vector for treatment of Cystinosis. $11,999,944
jCyte, Inc Henry John Klassen Clinical Trial Stage Projects A Phase 2 Study of the Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects with Retinitis Pigmentosa $5,175,000
University of California, San Francisco Peter Stock Clinical Trial Stage Projects Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Diabetes in the Intra-Muscular Site: PARADIGM $11,083,012
Jasper Therapeutics, Inc. Wendy Pang Clinical Trial Stage Projects A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants $2,313,398
Stanford University Dr. Everett H. Meyer Clinical Trial Stage Projects Induction of Tolerance by Combinatorial Therapy w/ Donor Stem Cells and Expanded Recipient Treg cells in HLA-mismatched Kidney Transplant Recipients $11,955,585
City of Hope, Beckman Research Institute Dr. De-Fu Zeng Clinical Trial Stage Projects Treatment of sickle cell disease by induction of mixed chimerism and immune tolerance using CD4+ T-depleted haploidentical blood stem cell transplant $4,352,180
University of California, San Francisco Mort Cowan Clinical Trial Stage Projects Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells $12,000,000
University of California, Los Angeles Dr. Steven M. Dubinett MD Clinical Trial Stage Projects A phase I trial of intratumoral administration of CCL21-gene modified dendritic cell (DC) combined with intravenous pembrolizumab for advanced NSCLC $10,955,315
Medeor Acquisition Corp. Daniel Brennan Clinical Trial Stage Projects Cellular Immunotherapy for Induction of Immune Tolerance in HLA Matched Living Donor Kidney Transplant Recipients $11,217,155
Children’s Hospital of Los Angeles Michael A. Pulsipher Clinical Trial Stage Projects Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Before or After Hematopoietic Stem Cell Transplantation (ACES) $4,825,587
jCyte, Inc Henry John Klassen Clinical Trial Stage Projects Phase 2b Clinical Study of Safety and Efficacy of Intravitreal Injection of Retinal Progenitor Cells (jCell) for Treatment of Retinitis Pigmentosa $8,295,750
Stanford University Dr Robert Lowsky Clinical Trial Stage Projects Induction of Tolerance to Combined Kidney and Hematopoietic Progenitor Cell Transplants from HLA Haplotype Matched Living Donors $6,653,266
University of California, Los Angeles Dr. Donald B. Kohn PhD Clinical Trial Stage Projects Efficacy and safety of cryopreserved autologous CD34+ HSC transduced with EFS lentiviral vector encoding for human ADA gene in ADA-SCID subjects $5,827,000
University of California, San Francisco Dr. Tippi C. MacKenzie MD Clinical Trial Stage Projects In Utero Hematopoietic Stem Cell Transplantation For The Treatment Of Fetuses With Alpha Thalassemia Major $9,350,000
University of California, Davis Dr Mehrdad Abedi Clinical Trial Stage Projects Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-selected CD34+ Cells in AIDS lymphoma patients $8,414,265
University of California, Los Angeles Dr. Donald B. Kohn PhD Clinical Trial Stage Projects A Phase I/II, Non Randomized, Multicenter, Open-Label Study of G1XCGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease $7,083,364
Rejuvenate Bio Deborah D. Ascheim Late Stage Preclinical Projects Novel Gene Therapy Targeting Multiple Pathological Drivers of Desmoplakin Associated Arrhythmogenic Cardiomyopathy $4,000,000
University of California, San Diego Mark H Tuszynski Late Stage Preclinical Projects Human Embryonic Stem Cell-Derived Neural Stem Cells for Severe Spinal Cord Injury (SCI) $6,000,000
University of California, Los Angeles Dr. Arjun Deb Late Stage Preclinical Projects Development of a therapeutic monoclonal antibody for the treatment of myocardial infarction and heart failure $5,999,998
University of California, San Francisco Thomas Martin Late Stage Preclinical Projects A 1XX-enhanced and fully non-viral BCMA CAR T cell therapy for Relapsed and Refractory Multiple Myeloma (UCCT-BCMA-1) $4,585,501
Children’s Hospital of Los Angeles Shahab Asgharzadeh Late Stage Preclinical Projects Chimeric TGFB Signaling Receptor (CTSR) Enabled Anti-B7H3 CAR T-cell Therapy in Children and AYA with Recurrent Solid Tumors $6,000,000
Elpida Therapeutics Mr Terry Pirovolakis Late Stage Preclinical Projects Pre-Clinical To Clinical Gene Therapy Development For CMT4J $3,930,964
Cedars-Sinai Medical Center Dr. Eugenio Cingolani Late Stage Preclinical Projects Extracellular Vesicles for Ventricular Tachycardia $5,999,441
City of Hope, Beckman Research Institute Prof. Karen S Aboody M.D. Late Stage Preclinical Projects Neural stem cell delivered CRAd-S-pk7 oncolytic viro-immunotherapy for ovarian cancer $5,314,547
Mahzi Therapeutics Dr. Yael Weiss Late Stage Preclinical Projects Development of a Gene Therapy for the Treatment of WWOX related epileptic encephalopathy (WOREE) $4,000,000
Tr1X Inc. Dr. Maria Grazia Roncarolo Late Stage Preclinical Projects TRX103 for prevention of GvHD in patients receiving HLA mismatched related or unrelated allogeneic HSCT for the treatment of hematologic malignancies. $4,000,000
University of California, Irvine Kyriacos A Athanasiou Late Stage Preclinical Projects Treatment of the TMJ disc complex $6,000,000
Stanford University Dr. Matthew H Porteus Late Stage Preclinical Projects Autologous Gene Corrected Sinus Basal Cells to Treat Serious Cystic Fibrosis Sinus Disease $6,000,000
Aspera Biomedicines, Inc. Catriona Jamieson Late Stage Preclinical Projects Cancer Stem Cell Interception with Rebecsinib: A First-in-Class ADAR1 Inhibitor $3,200,000
University of California, Los Angeles Dr. Jerome A. Zack Ph.D. Late Stage Preclinical Projects Clinical Translation of Autologous Regenerative Pluripotent Stem Cell Therapy for Blindness $6,000,000
Rampart Bioscience Jeffrey Bartlett Late Stage Preclinical Projects Ex vivo Engineering of Autologous Hematopoietic Stem Cells for the Treatment of Hypophosphatasia $3,999,980
Kenai Therapeutics Howard J Federoff Late Stage Preclinical Projects Allogeneic iPSC derived Dopaminergic Drug Product for Parkinson’s disease $4,000,000
Nammi Therapeutics, Inc. Dr. David R Stover Late Stage Preclinical Projects IND-Enabling activities for the masked immunocytokine, QXL138AM $3,999,113
Calidi Biotherapeutics, Inc. 8587949607 Boris Minev Late Stage Preclinical Projects Allogeneic mesenchymal stem cells loaded with oncolytic virus for cancer treatment $3,111,467
University of California, Davis Dr. Joseph S Anderson Late Stage Preclinical Projects Hematopoetic stem cell gene therapy for the treatment of Tay-Sachs disease $4,048,253
Ossium Health, Inc. Dr. Brian Johnstone Late Stage Preclinical Projects Development of OSSM-007, cryopreserved interferon-gamma primed allogeneic MSCs, for treatment of steroid refractory acute graft versus host disease $3,457,858
Stanford University Natalia Gomez-Ospina Late Stage Preclinical Projects Genome Editing of Autologous Hematopoietic Stem Cells to Treat Severe Mucopolysaccharidosis type 1 (Hurler Syndrome) $5,444,353
University of California, San Francisco Dr. Karin Lindgren Gaensler Late Stage Preclinical Projects Development of TriLeukeVax, an Engineered Autologous Leukemia Vaccine for Stimulating Cytolytic Immune Responses to Residual Leukemic Stem Cells $6,000,000
University of California, Los Angeles Dr. Antoni Ribas MD/PhD Late Stage Preclinical Projects Skin regeneration and wound healing with a topical BRAF inhibitor $5,005,126
ImmunoVec Dr. Ryan L. Wong Late Stage Preclinical Projects Hematopoietic Stem Cell Gene Therapy for XCGD $3,999,959
University of Southern California Dr. Denis A Evseenko Dr. Late Stage Preclinical Projects Plurocart: a novel stem cell-based implant for articular cartilage restoration $5,999,782
University of California, San Diego Thomas J Kipps Late Stage Preclinical Projects Late Stage Pre-Clinical Development of a Cirmtuzumab Based CAR T-cell for the Treatment of ROR1+ Hematological Malignancies $2,160,000
City of Hope, Beckman Research Institute Dr. Angelo Manuel Almeida Cardoso Ph.D., MD Late Stage Preclinical Projects Ex Vivo Gene Engineering of Blood Stem Cells for Enhanced Chemotherapy Efficacy in Glioblastoma Patients $3,684,259
University of California, Irvine Dr. Leslie M Thompson Late Stage Preclinical Projects An hESC-derived hNSC Therapeutic for Huntington’s Disease $5,635,393
University of California, Los Angeles Dr. Donald B. Kohn PhD Disease Team Therapy Development III Clinical Trial of Stem Cell Gene Therapy for Sickle Cell Disease $13,145,465
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