Mechanisms of small RNA regulation in early embryonic development
The promise of embryonic stem cells in regenerative medicine is based on their potential to make every cell in the body, a property coined pluripotency. With rapid recent advances in…
Mechanisms Underlying the Diverse Functions of STAT3 in Embryonic Stem Cell Fate Regulation
Embryonic stem cells (ESCs) are derived from very early stage embryos. ESCs can be maintained in culture indefinitely while retain the ability to make any type of cell in the…
Translational epigenomics: dissecting cell type-specific function of neuropsychiatric risk genes in vivo
Research Objective Our objective is to enable scalable genetic screening to study how different cell types and epigenetic networks are impacted by risk genes implicated in human psychiatric disorders. Impact…
Shared Resources Laboratory for Stem Cell-Based Modeling in Stem Cell Biology and Engineering
We propose to expand and enhance our stem cell core, a key resource for the local area.This project will accelerate new therapies and train stem cell scientists. We propose to…
A modular automation approach to stem cell modeling to increase throughput, reproducibility and access
This project enhances stem cell access, scalability, and collaboration. It offers characterized hPSC lines, CRISPR editing, and differentiation on automated platforms accelerating progress in biology, disease research, and regenerative medicine.…
High-Throughput Discovery of Embryo Formation Factors Using Stem Cell-Based Human Embryo Models
Research Objective To integrate emulsion microfluidics-based encapsulation with AI-powered imaging to develop a high-throughput pipeline for stem cell-based embryo models. Impact We will overcome key bottlenecks to drive breakthroughs in…
Dissecting the cellular and molecular interactions between embryo and endometrium during human implantation.
Research Objective This research will define the dynamic mechanisms of human embryo implantation by integrating live imaging, spatial multi-omics, and gene editing in physiologically relevant stem cell-based models. Impact This…
Genetic and Epigenetic Regulation of XIST and X-chromosome silencing in hiPSCs: Overcoming Barriers in Stem Cell-Based Therapies for Women’s Health
Research Objective We study how the inactive X chromosome aberrantly reactivates in female pluripotent stem cells and develop ways to prevent it, enabling accurate modeling of female biology for research…
Development of in vitro and in vivo functional human synthetic kidney organoid (hSKO) model as a platform technology for kidney research
Research Objective Development of a human stem cell-derived, spatially-patterned, mature and functional human synthetic kidney organoid (hSKO) model as a platform technology for basic and translational kidney research. Impact Lack…
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