Human Stem Cell Use: iPS Cell
The Childrens Hospital of Los Angeles hESC Facility
Our institution is a tertiary-care academic pediatric medical center that combines care of severely ill children, research into the causes and treatments of childhood disorders, and training of the next generation of pediatric clinical physicians, nurses and allied health care professionals and biomedical scientists. A unique focus of the research in our institution is on […]
UCSC Shared Stem Cell Facility
We have assembled a team of researchers with the aim of elucidating the molecular and cellular mechanisms that regulate stem cell self renewal and differentiation. Drawing on their broad range of expertise in development, genetics, genomics, molecular, cell and computational biology, these researchers will use interdisciplinary approaches to tackle problems concerning how genes are regulated […]
TSRI Center for hESC Research
The therapeutic use of stem cells in regenerative medicine will require the ability to control stem cell expansion and differentiation into specific tissue types, such as pancreatic ?-cells, heart tissue, bone or specific neuronal lineages. We have taken a chemical approach toward this problem in which large collections of synthetic small molecules are being screened […]
USC Center for Stem Cell and Regenerative Medicine: Shared Research Laboratory and Course in Current Protocols in Human Embryonic Stem Cell Research
To realize the potential of human embryonic stem cells (hESC) in research and medicine, it is essential to disseminate state of the art technology in this field to the scientific community at large. The Shared Research Laboratory (SRL) of the Center for Stem Cell and Regenerative Medicine (CSCRM) at the University of Southern California will […]
The University of California: Irvine Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course
A major goal of the Shared Research Laboratory (SRL) is to foster the development of new treatments for human diseases and disorders by serving as a leading regional center for human embryonic stem cell (hESC) research, clinical applications, and training. A critical component of this vision is a full service SRL. The SRL will provide […]
Collaborative Laboratory for Human Embryonic Stem Cell Research at Sanford-Burnham Medical Research Institute
We are proposing to expand our “safe haven” human embryonic stem cell laboratory to accommodate the enormous interest in scientific research in this field, and to provide an environment that is conducive to the goals of the CIRM’s Strategic Plan. Our collaborative Shared Laboratory will support the research of all of our institution’s many stem […]
North Bay CIRM Shared Research Laboratory for Stem Cells and Aging
Age-related diseases of the nervous system are major challenges for biomedicine in the 21st century. These disorders, which include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and stroke, cause loss of neural tissue and functional impairment. Currently, there is no cure for these devastating neurological disorders. A promising approach to the treatment of […]
Shared viral vector facility for genetic manipulation of huamn ES cell
Human ES (hES) cells offer the opportunity to be converted into replacement tissues for diseased organs and provide cures for diseases like Parkinson’s, diabetes, and a host of neurological disorders. Unfortunately due to political considerations, scientific space containing equipment and other resources provided by the federal government are off limits for work on unapproved hES […]
Defining the Isoform-Specific Effects of Apolipoprotein E on the Development of iPS Cells into Functional Neurons in Vitro and in Vivo
GOALS We propose to determine the effects of different forms of apoE on the development of induced pluripotent stem (iPS) cells into functional neurons. In Aim 1, iPS cells will be generated from skin cells of adult knock-in (KI) mice expressing different forms of human apoE and in humans with different apoE genotypes. In Aim […]
Molecular mechanisms governing hESC and iPS cell self-renewal and pluripotency
A major problem in regenerative medicine today is that stem cells have the ability to cause tumors and in most cases we currently lack methods to make them safe. For example, two of the most promising stem cells for regenerative medicine, human embryonic stem cells (hESC) and induced pluripotent stem cells (iPS), both readily cause […]