Our institution is a tertiary-care academic pediatric medical center that combines care of severely ill children, research into the causes and treatments of childhood disorders, and training of the next…
We have assembled a team of researchers with the aim of elucidating the molecular and cellular mechanisms that regulate stem cell self renewal and differentiation. Drawing on their broad range…
The therapeutic use of stem cells in regenerative medicine will require the ability to control stem cell expansion and differentiation into specific tissue types, such as pancreatic ?-cells, heart tissue,…
To realize the potential of human embryonic stem cells (hESC) in research and medicine, it is essential to disseminate state of the art technology in this field to the scientific…
A major goal of the Shared Research Laboratory (SRL) is to foster the development of new treatments for human diseases and disorders by serving as a leading regional center for…
We are proposing to expand our “safe haven” human embryonic stem cell laboratory to accommodate the enormous interest in scientific research in this field, and to provide an environment that…
Age-related diseases of the nervous system are major challenges for biomedicine in the 21st century. These disorders, which include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and stroke,…
Human ES (hES) cells offer the opportunity to be converted into replacement tissues for diseased organs and provide cures for diseases like Parkinson’s, diabetes, and a host of neurological disorders.…
GOALS We propose to determine the effects of different forms of apoE on the development of induced pluripotent stem (iPS) cells into functional neurons. In Aim 1, iPS cells will…
A major problem in regenerative medicine today is that stem cells have the ability to cause tumors and in most cases we currently lack methods to make them safe. For…
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