Development of COVID-19 Antiviral Therapy Using Human iPSC-Derived Lung Organoids

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Grant Award Details

Grant Type:
Quest – Discovery Stage Research Projects
Grant Number:
DISC2-12170
Investigator(s):
Name:
Tariq M Rana
Institution:
University of California, San Diego
Type:
PI

Disease Focus:
COVID-19, Infectious Disease
Human Stem Cell Use:
iPS Cell
Award Value:
$250,000
Status:
Closed

Progress Reports

Reporting Period:
Year 1/NCE period

Grant Application Details

Application Title:

Development of COVID-19 Antiviral Therapy Using Human iPSC-Derived Lung Organoids

Public Abstract:
Research Objective

To develop a new therapy for COVID-19 using human iPSC-derived lung organoids that targets SARS-CoV-2 protease known as the virus’ “Achilles Heel”

Impact

Our work, if successful, will bring a class of new drugs directly targeting viral enzyme and open the door for future COVID therapies.

Major Proposed Activities

  • Complete synthesis and testing of new inhibitors
  • Optimize and validate the new compounds activities in lung cells and organoids
  • Rapidly expand the efficacy of SARS-CoV-2 inhibitors in a large panel of lung organoids from African-American, Latino, and Caucasian men and women.
  • ensure that any newly emerging therapy will be applicable to all patients regardless of gender and race.
Statement of Benefit to California:
The emergence of novel coronavirus SARS-CoV-2 and its associated disease, COVID-19, has presented an urgent global public health crisis. In California, more than 700,000 individuals have been infected leading ~13,000 deaths. Further, Californians are grappling with the economic impact due to job loss and business shutdowns. Finding a treatment for COVID-19 would have a huge impact on saving lives, preventing new infections, and helping people to return to normal activities of life.

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