Human induced pluripotent stem cells-derived glial enriched progenitors for the treatment of mild traumatic brain injury
Grant Award Details
Grant Type:
Grant Number:
DISC2-16562
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$2,255,189
Status:
Active
Grant Application Details
Application Title:
Human induced pluripotent stem cells-derived glial enriched progenitors for the treatment of mild traumatic brain injury
Public Abstract:
Research Objective
Allogeneic human induced pluripotent stem cell-derived glial enriched progenitor cell therapy to treat mild traumatic brain injury
Impact
Prior to this study, glial cell-based therapies have never been tested as a therapeutic candidate for the treatment of mild traumatic brain injury .
Major Proposed Activities
Allogeneic human induced pluripotent stem cell-derived glial enriched progenitor cell therapy to treat mild traumatic brain injury
Impact
Prior to this study, glial cell-based therapies have never been tested as a therapeutic candidate for the treatment of mild traumatic brain injury .
Major Proposed Activities
- Milestone 1- Determine hiPSC-GEPs efficacy
- Milestone 2- Characterize hiPSC-GEPs-induced mechanism of repair
- Milestone 3- Determine plasticity and neural network connectivity changes
Statement of Benefit to California:
Mild traumatic brain injury is a devastating disease with no treatment. It is estimated that 100 to 300 per 100,000 people seek medical attention for mTBI annually worldwide. Nearly 32,900 people diagnosed with a non-fatal TBI are hospitalized in California each year. There is a crucial need for better therapeutic treatments towards enhancing recovery and rehabilitative mechanisms after mTBI.
