Human iPSC-derived micro-heart muscles for high-throughput cardiac drug discovery
Grant Award Details
Grant Type:
Grant Number:
TRAN4-13022
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$1,119,382
Status:
Active
Progress Reports
Reporting Period:
Final Operational Milestone #4
Grant Application Details
Application Title:
Human iPSC-derived micro-heart muscles for high-throughput cardiac drug discovery
Public Abstract:
Translational Candidate
In vitro miniaturized array of heart muscle amenable for use in efficient high-throughput drug discovery and screening campaigns.
Area of Impact
Effective high-throughput screening of drugs on human heart muscles does not exist, hindering the discovery of therapeutics to treat heart failure.
Mechanism of Action
Current approaches for drug discovery often miss a vast majority of druggable targets. Our approach for high throughput screening will provide a new platform for the more efficient drug discovery in human heart muscles exhibiting physiological features and drug responses, which cannot be achieved in 2D cardiac preparations. The proposed tool can be used in large-scale screening campaigns for de novo cardiovascular drug discovery or drug repurposing, at a reduced cost.
Unmet Medical Need
Innovation in heart failure therapeutics is lacking, despite the severity of the disease. Current pharmacologic approaches are suboptimal, thus mortality associated to heart failure remains high. Developing a tool for high-throughput drug discovery will lead to improved pharmacologic treatments.
Project Objective
High-throughput drug discovery and screening tool.
Major Proposed Activities
In vitro miniaturized array of heart muscle amenable for use in efficient high-throughput drug discovery and screening campaigns.
Area of Impact
Effective high-throughput screening of drugs on human heart muscles does not exist, hindering the discovery of therapeutics to treat heart failure.
Mechanism of Action
Current approaches for drug discovery often miss a vast majority of druggable targets. Our approach for high throughput screening will provide a new platform for the more efficient drug discovery in human heart muscles exhibiting physiological features and drug responses, which cannot be achieved in 2D cardiac preparations. The proposed tool can be used in large-scale screening campaigns for de novo cardiovascular drug discovery or drug repurposing, at a reduced cost.
Unmet Medical Need
Innovation in heart failure therapeutics is lacking, despite the severity of the disease. Current pharmacologic approaches are suboptimal, thus mortality associated to heart failure remains high. Developing a tool for high-throughput drug discovery will lead to improved pharmacologic treatments.
Project Objective
High-throughput drug discovery and screening tool.
Major Proposed Activities
- Fabrication of the high-throughput screening tool to identify drugs to treat heart disease
- Validate the heart muscle platform with an FDA-approved compound library
- Test healthy and diseased population variability in drug effect on cardiac contractility
Statement of Benefit to California:
Although heart disease is the leading cause of death in California, decades-old drugs are still mainstays of therapy, despite causing arrhythmia and hypotension. The speedy development of treatments for heart disease is hindered by poorly predictive cardiac heart tissue models. Our tool enables high throughput testing of compounds on heart function for faster and more effective identification of new drugs to treat heart disease, an enormous benefit for the healthcare of Californians.